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4'-hydroxybupivacaine

Known as: 4-Hydroxybupivacaine 
National Institutes of Health

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2 relations

Broader (1)

Bupivacaine
analogs & derivatives

Papers overview

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2012
2012
Structural elucidation of phase I and II metabolites of bupivacaine in horse urine and fungi of the Cunninghamella species using liquid chromatography/multi-stage mass spectrometry.
RATIONALE Bupivacaine is a local anaesthetic prohibited in equine sports. It is highly metabolized in the horse but a thorough… 
1999
1999
Bupivacaine in the horse: relationship of local anaesthetic responses and urinary concentrations of 3-hydroxybupivacaine.
Bupivacaine is a potent local anaesthetic used in equine medicine. It is also classified as a Class 2 foreign substance by the… 
1999
1999
Stereoselective urinary excretion of bupivacaine and its metabolites during epidural infusion.
A sensitive and efficient chiral assay for bupivacaine and its three principal metabolites desbutylbupivacaine, 4… 
1998
1998
Determination of bupivacaine and three of its metabolites in rat urine by capillary electrophoresis
A capillary electrophoretic (CE) method for the analysis of urinary extracts of the local anesthetic, bupivacaine, and its three… 
1994
1994
Column liquid chromatographic determination of bupivacaine in human serum using solid-phase extraction.
1992
1992
High-performance liquid chromatographic method for the quantitation of bupivacaine, 2,6-pipecoloxylidide and 4'-hydroxybupivacaine in plasma and urine.
1991
1991
Cumulation of bupivacaine, desbutylbupivacaine and 4‐hydroxybupivacaine during and after continuous interscalene brachial plexus block
Desbutylbupivacaine (DBB) and 4‐hydroxybupivacaine (4‐OHB) are major metabolites of bupivacaine. They may cumulate during… 
1991
1991
Plasma concentrations of bupivacaine and two of its metabolites during continuous interscalene brachial plexus block.
An interscalene brachial plexus block was performed via a catheter with 20-28 ml of 0.75% bupivacaine plus adrenaline for surgery… 
1988
1988
Lack of effect of cimetidine on the pharmacokinetics of bupivacaine in healthy subjects.
1. The possibility of a pharmacokinetic interaction between the H2-receptor antagonist cimetidine and the long-acting local… 
1986
1986
Simultaneous determination of bupivacaine and its two metabolites, desbutyl- and 4'-hydroxybupivacaine, in human serum and urine.
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