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3-phosphoinositide-dependent protein kinase

Known as: Protein Kinases, 3-Phosphoinositide-Dependent, 3 Phosphoinositide Dependent Protein Kinase, 3-Phosphoinositide-Dependent Protein Kinases 
Highly conserved protein-serine threonine kinases that phosphorylate and activate a group of AGC protein kinases, especially in response to the… Expand
National Institutes of Health

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Related topics

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3-Phosphoinositide Dependent Protein Kinase-13-Phosphoinositide Dependent Protein Kinase-2PDPK1 protein, humanPKH1 protein, S cerevisiae
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In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer.
Oncogenic Kras activates a plethora of signaling pathways, but our understanding of critical Ras effectors is still very limited… Expand
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Review
2012
Review
2012
PI3K-PKB/Akt pathway.
Protein kinase B (PKB, or Akt) plays a role in cell metabolism, growth, proliferation, and survival. Its activation is controlled… Expand
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Highly Cited
2012
Highly Cited
2012
3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner.
3-phosphoinositide-dependent protein kinase 1 (PDK1) is the pivotal element of the phosphatidylinositol 3 kinase (PI3K) signaling… Expand
Highly Cited
2011
Highly Cited
2011
IκB kinase ε and TANK-binding kinase 1 activate AKT by direct phosphorylation
AKT activation requires phosphorylation of the activation loop (T308) by 3-phosphoinositide-dependent protein kinase 1 (PDK1) and… Expand
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2008
2008
Phosphatidylinositide Dependent Kinase Deficiency Increases Anxiety and Decreases GABA and Serotonin Abundance in the Amygdala
Pathological anxiety is paralleled by deficits in serotonergic and GABAergic neurotransmission in the amygdala. Conversely… Expand
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Highly Cited
2006
Highly Cited
2006
Phosphorylation and activation of PINOID by the phospholipid signaling kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1) in Arabidopsis.
Activity of the serine-threonine protein kinase PINOID (PID) has been implicated in the asymmetrical localization of the membrane… Expand
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Highly Cited
2000
Highly Cited
2000
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
BACKGROUND Protein kinase B (PKB), and the p70 and p90 ribosomal S6 kinases (p70 S6 kinase and p90 Rsk, respectively), are… Expand
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Highly Cited
2000
Highly Cited
2000
Rho GTPase Control of Protein Kinase C-related Protein Kinase Activation by 3-Phosphoinositide-dependent Protein Kinase*
The protein kinase C-related protein kinases (PRKs) have been shown to be under the control of the Rho GTPases and influenced by… Expand
Highly Cited
1999
Highly Cited
1999
Domain Swapping Used To Investigate the Mechanism of Protein Kinase B Regulation by 3-Phosphoinositide-Dependent Protein Kinase 1 and Ser473 Kinase
ABSTRACT Protein kinase B (PKB or Akt), a downstream effector of phosphoinositide 3-kinase (PI 3-kinase), has been implicated in… Expand
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Highly Cited
1998
Highly Cited
1998
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
BACKGROUND The p70 S6 kinase, an enzyme critical for cell-cycle progression through the G1 phase, is activated in vivo by insulin… Expand
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