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3-phosphoinositide-dependent protein kinase

Known as: Protein Kinases, 3-Phosphoinositide-Dependent, 3 Phosphoinositide Dependent Protein Kinase, 3-Phosphoinositide-Dependent Protein Kinases 
Highly conserved protein-serine threonine kinases that phosphorylate and activate a group of AGC protein kinases, especially in response to the… (More)

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Topic mentions per year

1997-2018
051019972018

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In BloodProcess of secretionadministration & dosageantagonists & inhibitors
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PDPK1 protein, human

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
3-phosphoinositide-dependent protein kinase
physiological aspects
chemical synthesis
standards characteristics
Process of secretion
PDPK1 protein, human

Papers overview

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2010
2010
Regulation of 3-phosphoinositide-dependent protein kinase 1 activity by homodimerization in live cells.
3-Phosphoinositide-dependent kinase 1 (PDK1) plays a central role in regulating the activity of protein kinases that are… (More)
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Highly Cited
2007
Highly Cited
2007
Intramolecular and Intermolecular Interactions of Protein Kinase B Define Its Activation In Vivo
Protein kinase B (PKB/Akt) is a pivotal regulator of diverse metabolic, phenotypic, and antiapoptotic cellular controls and has… (More)
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2006
2006
Phosphorylation and activation of PINOID by the phospholipid signaling kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1) in Arabidopsis.
Activity of the serine-threonine protein kinase PINOID (PID) has been implicated in the asymmetrical localization of the membrane… (More)
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2005
2005
The subcellular localization of 3-phosphoinositide-dependent protein kinase is controlled by caveolin-1 binding.
3-Phosphoinositide-dependent protein kinase 1 (PDK1), a member of the serine/threonine kinase family, has been demonstrated to be… (More)
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2004
2004
Pil1p and Lsp1p negatively regulate the 3-phosphoinositide-dependent protein kinase-like kinase Pkh1p and downstream signaling pathways Pkc1p and Ypk1p.
The Saccharomyces cerevisiae homologs, Pkh1/2p, of the mammalian 3-phosphoinositide-dependent protein kinase 1 (PDK1) regulate… (More)
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Highly Cited
2000
Highly Cited
2000
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
BACKGROUND Protein kinase B (PKB), and the p70 and p90 ribosomal S6 kinases (p70 S6 kinase and p90 Rsk, respectively), are… (More)
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2000
2000
Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase.
The protein kinase C-related protein kinases (PRKs) have been shown to be under the control of the Rho GTPases and influenced by… (More)
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Highly Cited
1999
Highly Cited
1999
Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro.
p70 S6 kinase alpha (p70alpha) is activated in vivo through a multisite phosphorylation in response to mitogens if a sufficient… (More)
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1999
1999
Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase.
Protein kinase B (PKB or Akt), a downstream effector of phosphoinositide 3-kinase (PI 3-kinase), has been implicated in insulin… (More)
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Highly Cited
1998
Highly Cited
1998
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
BACKGROUND The p70 S6 kinase, an enzyme critical for cell-cycle progression through the G1 phase, is activated in vivo by insulin… (More)
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