3-phosphoinositide-dependent protein kinase
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Oncogenic Kras activates a plethora of signaling pathways, but our understanding of critical Ras effectors is still very limited… Expand Protein kinase B (PKB, or Akt) plays a role in cell metabolism, growth, proliferation, and survival. Its activation is controlled… Expand 3-phosphoinositide-dependent protein kinase 1 (PDK1) is the pivotal element of the phosphatidylinositol 3 kinase (PI3K) signaling… Expand AKT activation requires phosphorylation of the activation loop (T308) by 3-phosphoinositide-dependent protein kinase 1 (PDK1) and… Expand Pathological anxiety is paralleled by deficits in serotonergic and GABAergic neurotransmission in the amygdala. Conversely… Expand Activity of the serine-threonine protein kinase PINOID (PID) has been implicated in the asymmetrical localization of the membrane… Expand BACKGROUND
Protein kinase B (PKB), and the p70 and p90 ribosomal S6 kinases (p70 S6 kinase and p90 Rsk, respectively), are… Expand The protein kinase C-related protein kinases (PRKs) have been shown to be under the control of the Rho GTPases and influenced by… Expand ABSTRACT Protein kinase B (PKB or Akt), a downstream effector of phosphoinositide 3-kinase (PI 3-kinase), has been implicated in… Expand BACKGROUND
The p70 S6 kinase, an enzyme critical for cell-cycle progression through the G1 phase, is activated in vivo by insulin… Expand