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3-phosphoinositide-dependent protein kinase

Known as: Protein Kinases, 3-Phosphoinositide-Dependent, 3 Phosphoinositide Dependent Protein Kinase, 3-Phosphoinositide-Dependent Protein Kinases 
Highly conserved protein-serine threonine kinases that phosphorylate and activate a group of AGC protein kinases, especially in response to the… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Oncogenic Kras activates a plethora of signaling pathways, but our understanding of critical Ras effectors is still very limited… Expand
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Review
2012
Review
2012
Protein kinase B (PKB, or Akt) plays a role in cell metabolism, growth, proliferation, and survival. Its activation is controlled… Expand
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2012
2012
3-phosphoinositide-dependent protein kinase 1 (PDK1) is the pivotal element of the phosphatidylinositol 3 kinase (PI3K) signaling… Expand
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Highly Cited
2011
Highly Cited
2011
AKT activation requires phosphorylation of the activation loop (T308) by 3-phosphoinositide-dependent protein kinase 1 (PDK1) and… Expand
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Highly Cited
2008
Highly Cited
2008
Insulin- and leptin-stimulated phosphatidylinositol-3 kinase (PI3K) activation has been demonstrated to play a critical role in… Expand
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Highly Cited
2006
Highly Cited
2006
Activity of the serine-threonine protein kinase PINOID (PID) has been implicated in the asymmetrical localization of the membrane… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Protein kinase B (PKB), and the p70 and p90 ribosomal S6 kinases (p70 S6 kinase and p90 Rsk, respectively), are… Expand
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Highly Cited
2000
Highly Cited
2000
The protein kinase C-related protein kinases (PRKs) have been shown to be under the control of the Rho GTPases and influenced by… Expand
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Highly Cited
1999
Highly Cited
1999
Protein kinase B (PKB or Akt), a downstream effector of phosphoinositide 3-kinase (PI 3-kinase), has been implicated in insulin… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND The p70 S6 kinase, an enzyme critical for cell-cycle progression through the G1 phase, is activated in vivo by insulin… Expand
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