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3-phosphoinositide-dependent protein kinase

Known as: Protein Kinases, 3-Phosphoinositide-Dependent, 3 Phosphoinositide Dependent Protein Kinase, 3-Phosphoinositide-Dependent Protein Kinases 
Highly conserved protein-serine threonine kinases that phosphorylate and activate a group of AGC protein kinases, especially in response to the… 
National Institutes of Health

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3-Phosphoinositide Dependent Protein Kinase-13-Phosphoinositide Dependent Protein Kinase-2PDPK1 protein, humanPKH1 protein, S cerevisiae
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Papers overview

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Highly Cited
2013
Highly Cited
2013
Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer.
Review
2012
Review
2012
PI3K-PKB/Akt pathway.
Protein kinase B (PKB, or Akt) plays a role in cell metabolism, growth, proliferation, and survival. Its activation is controlled… 
Highly Cited
2012
Highly Cited
2012
3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner.
3-phosphoinositide-dependent protein kinase 1 (PDK1) is the pivotal element of the phosphatidylinositol 3 kinase (PI3K) signaling… 
Highly Cited
2011
Highly Cited
2011
IκB kinase ε and TANK-binding kinase 1 activate AKT by direct phosphorylation
AKT activation requires phosphorylation of the activation loop (T308) by 3-phosphoinositide-dependent protein kinase 1 (PDK1) and… 
Highly Cited
2008
Highly Cited
2008
PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response.
Highly Cited
2006
Highly Cited
2006
Phosphorylation and activation of PINOID by the phospholipid signaling kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1) in Arabidopsis.
Activity of the serine-threonine protein kinase PINOID (PID) has been implicated in the asymmetrical localization of the membrane… 
Highly Cited
2000
Highly Cited
2000
Rho GTPase Control of Protein Kinase C-related Protein Kinase Activation by 3-Phosphoinositide-dependent Protein Kinase*
The protein kinase C-related protein kinases (PRKs) have been shown to be under the control of the Rho GTPases and influenced by… 
Highly Cited
2000
Highly Cited
2000
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
Highly Cited
1999
Highly Cited
1999
Domain Swapping Used To Investigate the Mechanism of Protein Kinase B Regulation by 3-Phosphoinositide-Dependent Protein Kinase 1 and Ser473 Kinase
ABSTRACT Protein kinase B (PKB or Akt), a downstream effector of phosphoinositide 3-kinase (PI 3-kinase), has been implicated in… 
Highly Cited
1998
Highly Cited
1998
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
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