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3-hydroxyanthranilate 3,4-dioxygenase activity

Known as: 3-hydroxyanthranilic oxygenase activity, 3-hydroxyanthranilic acid oxygenase activity, 3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing) 
Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+). [EC:1.13.11.6, RHEA:17956]
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Crystal structures of human 3-hydroxyanthranilate 3,4-dioxygenase with native and non-native metals bound in the active site.
3-Hydroxyanthranilate 3,4-dioxygenase (3HAO) is an enzyme in the microglial branch of the kynurenine pathway of tryptophan… 
2006
2006
Cloricromene effect on the enzyme activities of the tryptophan-nicotinic acid pathway in diabetic/hyperlipidemic rabbits.
2002
2002
Enzyme activities along the tryptophan-nicotinic acid pathway in alloxan diabetic rabbits.
1999
1999
Effects of Mitochondria and O‐Methoxybenzoylalanine on 3‐Hydroxyanthranilic Acid Dioxygenase Activity and Quinolinic Acid Synthesis
Abstract : The use of o‐methoxybenzoylalanine, a selective kynureninase inhibitor, has been proposed with the aim of reducing… 
Review
1999
Review
1999
Regulation of quinolinic acid synthesis by mitochondria and o-methoxybenzoylalanine.
o-Methoxybenzoylalanine, a selective kynureninase inhibitor, caused unexpected accumulation of 3-hydroxyanthranilic acid (3OH-ANA… 
1991
1991
4-Halo-3-hydroxyanthranilates are potent inhibitors of 3-hydroxyanthranilate oxygenase in the rat brain in vitro and in vivo.
3-Hydroxyanthranilic acid oxygenase (3HA0; E.C. 1.13.11.6) is the enzyme responsible for the metabolism of 3-hydroxyanthranilic… 
1991
1991
Liver 3-hydroxyanthranilic acid oxygenase activity in rainbow trout (Oncorhynchus mykiss).
1990
1990
Regioselective synthesis of 4-chloro-3-hydroxyanthranilic acid, a potent in vitro inhibitor of 3-hydroxyanthranilic acid oxygenase activity from rat brain
1989
1989
Preparation of 4-halo-3-hydroxyanthranilates and demonstration of their inhibition of 3-hydroxyanthranilate oxygenase activity in rat and human brain tissue.
The chemical syntheses of 4-fluoro-, 4-chloro-, and 4-bromo-3-hydroxyanthranilic acids are described. Their actions as inhibitors… 
Highly Cited
1987
Highly Cited
1987
Rat 3‐Hydroxyanthranilic Acid Oxygenase: Purification from the Liver and Immunocytochemical Localization in the Brain
Abstract: 3‐Hydroxyanthranilic acid oxygenase (3HAO; EC 1.13.11.6). the biosynthetic enzyme of the endogenous excitotoxin… 
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