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3-dechloroethylifosfamide

 
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
In this article, we present a liver–kidney co‐culture model in a micro fluidic biochip. The liver was modeled using HepG2/C3a and… Expand
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2005
2005
Mechanisms leading to ifosfamide (IF)-induced renal damage have not been fully elucidated. Recent work suggests that localized… Expand
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Highly Cited
2004
Highly Cited
2004
Repeated administration of agents (e.g., cancer chemotherapy) that can cause drug-induced nephrotoxicity may lead to acute or… Expand
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2004
2004
It has often been reported that the oxazaphosphorines ifosfamide and cyclophosphamide induce their own metabolism. This… Expand
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2001
2001
The autoinducible metabolic transformation of the anticancer agent ifosfamide involves activation through 4‐hydroxyifosfamide to… Expand
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1997
1997
Abstract The oxazaphosphorine antineoplastic ifosfamide (IF) is metabolized by two different initial pathways: ring oxidation… Expand
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1996
1996
The cytotoxic drug ifosfamide is subject to an extensive metabolism. This study reports the results of a pharmacokinetic study of… Expand
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Highly Cited
1993
Highly Cited
1993
The initial metabolism of the oxazaphosphorine cytostatic ifosfamide (IF) consists of two different pathways: ring oxidation at… Expand
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1993
1993
SummaryPhosphorus-31 nuclear magnetic resonance spectroscopy was used to analyze urine samples obtained from patients treated… Expand
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1992
1992
The metabolic oxidation of one of the chloroethyl groups of the antitumour drug ifosfamide leads to the formation of the inactive… Expand
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