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3-dechloroethylifosfamide

National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
In this article, we present a liver–kidney co‐culture model in a micro fluidic biochip. The liver was modeled using HepG2/C3a and… Expand
Highly Cited
2004
Highly Cited
2004
The initial metabolism of the oxazaphosphorine cytostatic ifosfamide (IF) consists of two different pathways: ring oxidation at… Expand
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Highly Cited
2004
Highly Cited
2004
Repeated administration of agents (e.g., cancer chemotherapy) that can cause drug-induced nephrotoxicity may lead to acute or… Expand
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2004
2004
It has often been reported that the oxazaphosphorines ifosfamide and cyclophosphamide induce their own metabolism. This… Expand
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2001
2001
The autoinducible metabolic transformation of the anticancer agent ifosfamide involves activation through 4‐hydroxyifosfamide to… Expand
1997
1997
Abstract The oxazaphosphorine antineoplastic ifosfamide (IF) is metabolized by two different initial pathways: ring oxidation… Expand
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1996
1996
The cytotoxic drug ifosfamide is subject to an extensive metabolism. This study reports the results of a pharmacokinetic study of… Expand
1995
1995
Ifosfamide (IFO) at a dose of 5 g/m2, was administered as a 24-h infusion to 15 patients with metastatic (12) or locally advanced… Expand
1992
1992
The metabolic oxidation of one of the chloroethyl groups of the antitumour drug ifosfamide leads to the formation of the inactive… Expand
1992
1992
[31P] nuclear magnetic resonance spectroscopy was used to analyze body fluids from patients treated with ifosfamide (IF). This… Expand