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3-deazaneplanocin

Known as: 3-deaza-neplanocin 
 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

3-deazaneplanocin A

Broader (1)

Adenosine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer
Histone lysine methylation regulates gene expression and cancer initiation. Bioinformatics analysis suggested that DOT1L, a… Expand
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Highly Cited
2013
Highly Cited
2013
Enhancer of zeste homolog 2 silences microRNA-218 in human pancreatic ductal adenocarcinoma cells by inducing formation of heterochromatin.
BACKGROUND & AIMS Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that is overexpressed by pancreatic ductal… Expand
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Highly Cited
2012
Highly Cited
2012
Maturation-related histone modifications in the PU.1 promoter regulate Th9-cell development.
Epigenetic histone modifications are thought to underlie the rapid memory immune response to recall antigen that develops after… Expand
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Highly Cited
2012
Highly Cited
2012
Targeting the enhancer of zeste homologue 2 in medulloblastoma
Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 that catalyzes the trimethylation… Expand
Review
2011
Review
2011
Aberrations of EZH2 in Cancer
Control of gene expression is exerted at a number of different levels, one of which is the accessibility of genes and their… Expand
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Highly Cited
2011
Highly Cited
2011
Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2
ABSTRACT Latent HIV proviruses are silenced as the result of deacetylation and methylation of histones located at the viral long… Expand
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2006
2006
Synthesis of neplanocin F analogues as potential antiviral agents.
Neplanocin F is a natural carbocyclic nucleoside. Herein, we describe the synthesis and antiviral activity of (+/-)-5'-deoxy… Expand
Highly Cited
2003
Highly Cited
2003
Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners.
Eight adenosine analogs, 3-deaza-adenosine (DZA), 3-deaza-(+/-)aristeromycin (DZAri), 2',3'-dideoxy-adenosine (ddAdo), 2',3… Expand
Highly Cited
1994
Highly Cited
1994
Conformationally locked nucleoside analogues. Synthesis of dideoxycarbocyclic nucleoside analogues structurally related to neplanocin C.
The glycon moiety of nucleosides in solution is known to exist in a rapid dynamic equilibrium between extreme northern and… Expand
Highly Cited
1986
Highly Cited
1986
3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60.
3-Deazaneplanocin, a new carbocyclic analog of adenosine, was synthesized as an inhibitor of S-adenosylhomocysteine hydrolase… Expand
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