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3-deazaneplanocin

Known as: 3-deaza-neplanocin 
 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

3-deazaneplanocin A

Broader (1)

Adenosine
analogs & derivatives

Papers overview

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2014
2014
Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer
Histone lysine methylation regulates gene expression and cancer initiation. Bioinformatics analysis suggested that DOT1L, a… Expand
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2013
2013
Enhancer of zeste homolog 2 silences microRNA-218 in human pancreatic ductal adenocarcinoma cells by inducing formation of heterochromatin.
BACKGROUND & AIMS Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that is overexpressed by pancreatic ductal… Expand
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2013
2013
Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS
BackgroundEmbryonal Rhabdomyosarcoma (RMS) is a pediatric soft-tissue sarcoma derived from myogenic precursors that is… Expand
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Highly Cited
2012
Highly Cited
2012
Maturation-related histone modifications in the PU.1 promoter regulate Th9-cell development.
Epigenetic histone modifications are thought to underlie the rapid memory immune response to recall antigen that develops after… Expand
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2012
2012
Targeting the enhancer of zeste homologue 2 in medulloblastoma.
Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 that catalyzes the trimethylation… Expand
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Review
2011
Review
2011
Aberrations of EZH2 in Cancer
Control of gene expression is exerted at a number of different levels, one of which is the accessibility of genes and their… Expand
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Highly Cited
2011
Highly Cited
2011
Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2.
Latent HIV proviruses are silenced as the result of deacetylation and methylation of histones located at the viral long terminal… Expand
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2006
2006
Synthesis of neplanocin F analogues as potential antiviral agents.
Neplanocin F is a natural carbocyclic nucleoside. Herein, we describe the synthesis and antiviral activity of (+/-)-5'-deoxy… Expand
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Review
2001
Review
2001
Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections.
Poxviruses continue to pose a major threat to human health. Monkeypox is endemic in central Africa, and the discontinuation of… Expand
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Highly Cited
1986
Highly Cited
1986
3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60.
3-Deazaneplanocin, a new carbocyclic analog of adenosine, was synthesized as an inhibitor of S-adenosylhomocysteine hydrolase… Expand
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