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3-deazaneplanocin A

National Institutes of Health

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3-deazaneplanocin

Papers overview

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Highly Cited
2014
Highly Cited
2014
3-Deazaneplanocin A (DZNep), an Inhibitor of the Histone Methyltransferase EZH2, Induces Apoptosis and Reduces Cell Migration in Chondrosarcoma Cells
Objective Growing evidences indicate that the histone methyltransferase EZH2 (enhancer of zeste homolog 2) may be an appropriate… 
Highly Cited
2013
Highly Cited
2013
DZNep, inhibitor of S-adenosylhomocysteine hydrolase, down-regulates expression of SETDB1 H3K9me3 HMTase in human lung cancer cells.
Highly Cited
2012
Highly Cited
2012
3‐Deazaneplanocin A is a promising therapeutic agent for the eradication of tumor‐initiating hepatocellular carcinoma cells
Recent advances in stem cell biology have identified tumor‐initiating cells (TICs) in a variety of cancers including… 
Highly Cited
2012
Highly Cited
2012
Molecular Mechanisms Involved in the Synergistic Interaction of the EZH2 Inhibitor 3-Deazaneplanocin A with Gemcitabine in Pancreatic Cancer Cells
Pancreatic ductal adenocarcinoma (PDAC) is characterized by overexpression of enhancer of Zeste homolog-2 (EZH2), which plays a… 
Highly Cited
2012
Highly Cited
2012
TP53 Genomic Status Regulates Sensitivity of Gastric Cancer Cells to the Histone Methylation Inhibitor 3-Deazaneplanocin A (DZNep)
Purpose: DZNep (3-deazaneplanocin A) depletes EZH2, a critical component of polycomb repressive complex 2 (PRC2), which is… 
Highly Cited
2011
Highly Cited
2011
S-adenosylhomocysteine hydrolase inhibition by 3-deazaneplanocin A analogues induces anti-cancer effects in breast cancer cell lines and synergy with both histone deacetylase and HER2 inhibition
Epigenetic abnormalities including abnormal histone methyltransferase activity contribute to breast cancer pathogenesis. An… 
Highly Cited
2009
Highly Cited
2009
DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
DNA methylation, histone modifications, and nucleosomal occupancy collaborate to cause silencing of tumor-related genes in cancer… 
Highly Cited
2009
Highly Cited
2009
BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A
IntroductionTreatment of breast cancer is becoming more individualized with the recognition of tumor subgroups that respond… 
Highly Cited
2000
Highly Cited
2000
Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor.
Highly Cited
1989
Highly Cited
1989
Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.
The neplanocin A analogue 3-deazaneplanocin A (2b) has been synthesized. A direct SN2 displacement on the cyclopentenyl mesylate… 
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