3-deazaneplanocin A

 
National Institutes of Health

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2014
2014
OBJECTIVE Growing evidences indicate that the histone methyltransferase EZH2 (enhancer of zeste homolog 2) may be an appropriate… (More)
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2012
2012
Recent advances in stem cell biology have identified tumor-initiating cells (TICs) in a variety of cancers including… (More)
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2012
2012
Pancreatic ductal adenocarcinoma (PDAC) is characterized by overexpression of enhancer of Zeste homolog-2 (EZH2), which plays a… (More)
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2011
2011
Polycomb group (PcG) protein-dependent histone methylation and ubiquitination drives chromatin compaction leading to reduced… (More)
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2010
2010
Epigenetic abnormalities including abnormal histone methyltransferase activity contribute to breast cancer pathogenesis. An… (More)
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Highly Cited
2009
Highly Cited
2009
The polycomb repressive complex (PRC) 2 contains 3 core proteins, EZH2, SUZ12, and EED, in which the SET (suppressor of… (More)
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Highly Cited
2009
Highly Cited
2009
DNA methylation, histone modifications, and nucleosomal occupancy collaborate to cause silencing of tumor-related genes in cancer… (More)
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2002
2002
3-deazaneplanocin A, an analog of adenosine, is a potent inhibitor of Ebola virus replication. A single dose early in infection… (More)
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1989
1989
The neplanocin A analogs, 3-deazaneplanocin A, 9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl)adenine (DHCA), and 9-(trans-2… (More)
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1986
1986
The mechanism of action of the cyclopentenyl analogue of 3-deazaadenosine (3-deazaneplanocin A or c3Nep) was investigated in the… (More)
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