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3-cyano-7-ethoxycoumarin

Known as: 2H-1-Benzopyran-3-carbonitrile, 7-ethoxy-2-oxo-, 3-CETC 
National Institutes of Health

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2 relations

Broader (2)

CoumarinsNitriles

Papers overview

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2016
2016
Drugs of environmental concern modify Solea senegalensis physiology and biochemistry in a temperature-dependent manner
The alerted presence in recent decades of pharmaceuticals has become an issue of environmental concern, and most of the… 
2011
2011
Aminoglycoside-induced suppression of CYP2C19*3 premature stop codon
Background CYP2C19 is a polymorphic enzyme that plays a pivotal role in the metabolism of 10% of clinically used drugs worldwide… 
2011
2011
Evaluation of the effects of 18 non-synonymous single-nucleotide polymorphisms of CYP450 2C19 on in vitro drug inhibition potential by a fluorescence-based high-throughput assay
To comprehensively understand the effects of CYP2C19 genetic polymorphisms on inhibition-based drug–drug interactions (DDIs), 18… 
2010
2010
Effects of cytochrome P450 inhibitors on the biotransformation of fluorogenic substrates by adult male rat liver microsomes and cDNA-expressed rat cytochrome P450 isoforms.
We have evaluated the use of a panel of six fluorogenic cytochrome P450 (CYP) substrates as a potential tool for rapid screening… 
2007
2007
Evaluation of 3-O-Methylfluorescein as a Selective Fluorometric Substrate for CYP2C19 in Human Liver Microsomes
Cytochrome P450 (P450) fluorometric high-throughput inhibition assays have been widely used for drug-drug interaction screening… 
Highly Cited
2004
Highly Cited
2004
Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible.
Azamulin [14-O-(5-(2-amino-1,3,4-triazolyl)thioacetyl)-dihydromutilin] is an azole derivative of the pleuromutilin class of… 
2002
2002
CYTOCHROME P 450 FLUOROMETRIC SUBSTRATES : IDENTIFICATION OF ISOFORM-SELECTIVE PROBES FOR RAT CYP 2 D 2 AND HUMAN CYP 3 A 4 .
We have tested a panel of 29 cDNA-expressed rat and human enzymes with 9 fluorometric substrates to determine the P450 isoform… 
1993
1993
Characterization of Clara and type II cells isolated from rat lung by fluorescence-activated flow cytometry.
A novel procedure for the isolation of Clara cells from rat lung is described. Single-cell suspensions from male F344/TOX rat… 
1991
1991
Biochemical and morphologic responses of rat nasal epithelia to hyperoxia.
Highly Cited
1988
Highly Cited
1988
A continuous fluorometric assay for cytochrome P-450-dependent mixed function oxidases using 3-cyano-7-ethoxycoumarin.
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