FAQ

3 alpha-hydroxy-4-pregnen-20-one

Known as: 3alpha-dihydroprogesterone, 3alphaHP 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2010
01219972010

Related topics

Related topics

1 relation

Broader (1)

3-hydroxypregn-4-en-20-one

Related mentions per year

Related mentions per year

1997-2010
19901995200020052010
3 alpha-hydroxy-4-pregnen-20-one
3-hydroxypregn-4-en-20-one

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Opposing actions of the progesterone metabolites, 5alpha-dihydroprogesterone (5alphaP) and 3alpha-dihydroprogesterone (3alphaHP) on mitosis, apoptosis, and expression of Bcl-2, Bax and p21 in human…
Previous studies have shown that breast tissues and breast cell lines convert progesterone (P) to 5alpha-dihydroprogesterone… (More)
Is this relevant?
2007
2007
Regulation of estrogen receptor (ER) levels in MCF-7 cells by progesterone metabolites.
Estradiol-17beta (E2) may participate in carcinoma of mammary cells containing estradiol receptors (ER) at sufficient levels… (More)
Is this relevant?
2006
2006
Dutasteride affects progesterone metabolizing enzyme activity/expression in human breast cell lines resulting in suppression of cell proliferation and detachment.
Recent evidence indicates that progesterone metabolites play important roles in regulating breast cancer. Previous studies have… (More)
Is this relevant?
Review
2006
Review
2006
Progesterone metabolites in breast cancer.
In the 70 years since progesterone (P) was identified in corpus luteum extracts, its metabolism has been examined extensively in… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
2005
2005
The role of progesterone metabolites in breast cancer: potential for new diagnostics and therapeutics.
Proliferative changes in the normal breast are known to be controlled by female sex steroids. However, only a portion of all… (More)
Is this relevant?
2005
2005
Membrane 5alpha-pregnane-3,20-dione (5alphaP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5alphaP and down-regulated by the progesterone metabolites, 3alpha…
Previous studies have shown that the progesterone metabolite, 5alpha-pregnane-3,20-dione (5alphaP), exhibits mitogenic and… (More)
Is this relevant?
2000
2000
The 4-pregnene and 5alpha-pregnane progesterone metabolites formed in nontumorous and tumorous breast tissue have opposite effects on breast cell proliferation and adhesion.
Progesterone is required for the full proliferative activity of the breasts and may be directly or indirectly involved in either… (More)
Is this relevant?
2000
2000
Plasma membrane receptors for the cancer-regulating progesterone metabolites, 5alpha-pregnane-3,20-dione and 3alpha-hydroxy-4-pregnen-20-one in MCF-7 breast cancer cells.
Recent observations indicate that the progesterone metabolite, 5alpha-pregnane-3,20-dione (5alphaP), which is produced at higher… (More)
Is this relevant?
1998
1998
Brief exposure of mice to 60 Hz magnetic fields reduces the analgesic effects of the neuroactive steroid, 3alpha-hydroxy-4-pregnen-20-one.
Relatively weak, extremely low frequency (ELF), magnetic fields have been shown to exert a variety of biological effects… (More)
Is this relevant?
1997
1997
Synthesis, metabolism and levels of the neuroactive steroid, 3alpha-hydroxy-4-pregnen-20-one (3alphaHP), in rat pituitaries.
The neuroactive steroid, 3a-hydroxy-4-pregnen-20-one (3alphaHP), is a metabolite of progesterone and a precursor of 3alpha… (More)
Is this relevant?