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3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)

Known as: 3alpha-Hydroxysteroid Dehydrogenase (B-specific), 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) [Chemical/Ingredient], 3 alpha-Hydroxysteroid Dehydrogenase (B-Specific) 
A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA… Expand
National Institutes of Health

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5 alpha-Dihydroprogesterone 3 alpha-Hydroxysteroid Oxidoreductase
DHRS9 geneDHRS9 protein, humanIn BloodProcess of secretion
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Papers overview

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Review
2004
Review
2004
Structure-function of human 3 alpha-hydroxysteroid dehydrogenases: genes and proteins.
Four soluble human 3 alpha-hydroxysteroid dehydrogenase (HSD) isoforms exist which are aldo-keto reductase (AKR) superfamily… Expand
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2003
2003
Effects of insulin-like growth factor I on steroidogenic enzyme expression levels in mouse leydig cells.
The role of IGF-I in Leydig cell maturation was studied by evaluation of: 1) steady state levels for nine mRNA species expressed… Expand
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Highly Cited
1998
Highly Cited
1998
Mutagenesis of 3 alpha-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases.
Rat liver 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD, E.C. 1.1.1.213, AKR1C9) is a member of the aldo-keto reductase (AKR… Expand
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Highly Cited
1997
Highly Cited
1997
Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular…
In androgen target tissues, 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) may regulate occupancy of the androgen receptor (AR… Expand
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Highly Cited
1995
Highly Cited
1995
Substrate Specificity, Gene Structure, and Tissue-specific Distribution of Multiple Human 3α-Hydroxysteroid Dehydrogenases (*)
We have expressed in Escherichia coli functionally active proteins encoded by two human cDNAs that were isolated previously by… Expand
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1995
1995
Effects of luteinizing hormone (LH) and androgen on steady state levels of messenger ribonucleic acid for LH receptors, androgen receptors, and steroidogenic enzymes in rat Leydig cell progenitors in…
Adult Leydig cells differentiate postnatally from mesenchymal-like progenitor cells. The relative scarcity of LH receptors (LHRs… Expand
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Highly Cited
1993
Highly Cited
1993
Differential localization of the 5 alpha-reductase and the 3 alpha-hydroxysteroid dehydrogenase in neuronal and glial cultures.
The activities of the 5 alpha-reductase [the enzyme that converts testosterone into dihydrotestosterone (DHT)] and 3 alpha… Expand
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Review
1993
Review
1993
Androgen and progesterone metabolism in the central and peripheral nervous system
This paper summarizes the most recent data obtained in the authors' laboratory on the metabolism of testosterone and progesterone… Expand
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1991
1991
Cloning and sequencing of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase.
Rat liver 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD, EC 1.1.1.50) is an NAD(P)(+)-dependent oxidoreductase which will… Expand
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Highly Cited
1981
Highly Cited
1981
Direct spectrophotometry of total bile acids in serum.
In this simple and direct method for determining total bile acids in serum, the serum was mixed with sodium pyruvate, a lactate… Expand
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