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Adenosinergic systems have been implicated in anxiety-like states, as caffeine can induce a state of anxiety in human beings… Expand Under normoxic conditions, macrophages from C57BL mice produce low levels of vascular endothelial growth factor (VEGF). Hypoxia… Expand Recent epidemiological studies have established an association between the common consumption of coffee or other caffeinated… Expand The objective of this study was to characterize the behavior induced by the N-methyl-D-aspartate receptor antagonist MK-801… Expand A series of 8-substituted derivatives of 3,7-dimethyl-1-propargylxanthine (DMPX) was synthesized and investigated as A2A… Expand Adenosine agonists inhibit TNF-alpha production in macrophage and monocytes, but the mechanism is unknown. Therefore, we studied… Expand 1 Purine analogues have been examined for anxiolytic‐ and anxiogenic‐like activity in mice, by use of the elevated plus‐maze. 2… Expand Methotrexate, a folate antagonist, is a potent antiinflammatory agent when used weekly in low concentrations. We examined the… Expand The A2 adenosine receptor agonist, CGS 21680 in nanomolar concentrations, reversibly increased in a concentration-dependent… Expand 3,7-Dimethyl-1-propargylxanthine (DMPX), a caffeine analog that exhibits in vitro selectivity for A2-adenosine receptors… Expand