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3,4-dihydroxypyrrolidin-2-one

Known as: 3,4-dihydroxy-pyrrolidin-2-one 
National Institutes of Health

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Pyrrolidinones

Papers overview

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2019
2019
Alkaloids from the stem barks of Erythrina stricta.
2014
2014
Synthesis of a cyclic isostere of α-methyl homoserine by a stereoselective acylation–alkylation sequence of a chiral γ-lactam
Starting from a chiral 4-hydroxymethyl pyrrolidin-2-one, an isostere of α-methyl homoserine tethered on a γ-lactam ring was… 
2011
2011
Simple preparation of new N -( 6-methyl-2-nitrophenyl-1,2,3,4- tetrahydroquinolin-4-yl) pyrrolidin-2-ones and their spectroscopic analysis
Objectives. To prepare new N-(1,2,3,4-tetrahydroquinolin-4-yl) pyrrolidin-2-one molecules and to characterize them by… 
2011
2011
Interaction of 5-(2, 4-dimethylbenzyl) pyrrolidin-2-one with selected antifungal drug target enzymes by in silico molecular docking studies
Currently the criteria used for selecting optimal new antifungal drug candidates include inhibitors of fungal cell wall… 
2008
2008
I2-Catalyzed enantioselective ring expansion of beta-lactams to gamma-lactams through a novel C3-C4 bond cleavage. Direct entry to protected 3,4-dihydroxypyrrolidin-2-one derivatives.
Molecular iodine (10 mol%) efficiently catalyzes the ring expansion of 4-oxoazetidine-2-carbaldehydes in the presence of tert… 
2008
2008
Application of RP-TLC technique for the determination of dissociation constants of 1-substituted pyrrolidin-2-one derivatives.
The procedures for measuring dissociation constants (pK(a)) of twenty 1-substituted pyrrolidin-2-one derivatives are described… 
2006
2006
Rapid separation of four main taxoids in Taxus species by a combined LLP-SPE-HPLC (PAD) procedure.
A method is described for the simultaneous determination of paclitaxel and three related taxoids, 10-deacetylbaccatin III (10-DAB… 
2003
2003
Estimation of the lipophilicity of antiarrhythmic and antihypertensive active 1-substituted pyrrolidin-2-one and pyrrolidine derivatives.
The lipophilicity of some antiarrhythmic and antihypertensive active 1-[2-hydroxy- or 1-[2-acetoxy-3-(4-aryl-1-piperazinyl)propyl… 
2002
2002
N-Arylated pyrrolidin-2-ones and morpholin-3-ones as potassium channel openers.
2000
2000
Preparation of 1,5-disubstituted pyrrolidin-2-ones.
1,5-Disubstituted pyrrolidin-2-ones 18a-g, 19a-h, and 20a-f were synthesized in good to excellent yields via the nucleophilic… 
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