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3'-deamino-3'-hydroxydoxorubicin
Known as:
3-DHD
, 5,12-Naphthacenedione, 10-((2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-
, hydroxyrubicin
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Epirubicin
Topoisomerase II Inhibitors
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphoma
Fen Yang
,
M. Jiang
,
Ming Q. Lu
,
P. Hu
,
Hongyun Wang
,
Ji Jiang
Front. Pharmacol.
2018
Corpus ID: 52112363
Objective: This phase Ia study was designed to assess the pharmacokinetic (PK) characters of free vincristine (F-VCR, refer to as…
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2007
2007
N-Benzyladriamycin-14-valerate (AD 198): A Non-Cardiotoxic Anthracycline That Is Cardioprotective through PKC-ϵ Activation
P. Hofmann
,
M. Israel
,
+5 authors
L. Lothstein
Journal of Pharmacology and Experimental…
2007
Corpus ID: 8794814
N-Benzyladriamycin-14-valerate (AD 198) is one of several novel anthracycline protein kinase C (PKC)-activating agents developed…
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2001
2001
Drug sequestration in cytoplasmic organelles does not contribute to the diminished sensitivity of anthracyclines in multidrug resistant K562 cells.
C. Loetchutinat
,
W. Priebe
,
A. Garnier-Suillerot
European journal of biochemistry
2001
Corpus ID: 25667534
Cells that acquire multidrug resistance (MDR) are characterized by a decreased accumulation of a variety of drugs. In addition…
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Highly Cited
2000
Highly Cited
2000
Inhibition of the P-glycoprotein- and multidrug resistance protein-mediated efflux of anthracyclines and calceinacetoxymethyl ester by PAK-104P.
C. Marbeuf-Gueye
,
M. Salerno
,
P. Quidu
,
A. Garnier-Suillerot
European journal of pharmacology
2000
Corpus ID: 21079026
Highly Cited
1997
Highly Cited
1997
Electrostatic and non-electrostatic contributions to the binding free energies of anthracycline antibiotics to DNA.
M. Bagiński
,
F. Fogolari
,
J. Briggs
Journal of molecular biology
1997
Corpus ID: 20661908
The knowledge about molecular factors driving simple ligand-DNA interactions is still limited. The aim of the present study was…
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1994
1994
P‐glycoprotein‐mediated efflux of hydroxyrubicin, a neutral anthracycline derivative, in resistant K562 cells
M. Borrel
,
M. fiallo
,
W. Priebe
,
A. Garnier-Suillerot
FEBS letters
1994
Corpus ID: 27193617
1994
1994
Hydroxyrubicin, a deaminated derivative of doxorubicin, inhibits mammalian DNA topoisomerase II and partially circumvents multidrug resistance
E. Solary
,
V. Ling
,
R. Perez-soler
,
W. Priebe
,
Y. Pommier
International journal of cancer
1994
Corpus ID: 35074846
In vivo effectiveness of doxorubicin remains restricted due to toxicity and drug resistance. Hydroxyrubicin is a synthetic analog…
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Highly Cited
1993
Highly Cited
1993
Removal of the basic center from doxorubicin partially overcomes multidrug resistance and decreases cardiotoxicity
W. Priebe
,
N. T. Van
,
T. Burke
,
R. Perez-soler
Anti-cancer drugs
1993
Corpus ID: 23418147
Hydroxyrubicin, a synthetic doxorubicin analog in which the basic amino group at C-3' is replaced by a hydroxyl group, was used…
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1984
1984
Synthesis and antitumor activity of 3'-deamino-3'-hydroxydoxorubicin. A facile procedure for the preparation of doxorubicin analogs.
D. Horton
,
W. Priebe
,
O. Varela
The Journal of antibiotics
1984
Corpus ID: 43150324
Two successful routes have been developed for preparation of 3'-deamino-3'-hydroxydoxorubicin (11), based on protection of the 14…
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1984
1984
3'-Deamino-4'-epi-3'-hydroxy-daunorubicin and -doxorubicin. Synthesis and antitumor activity.
D. Horton
,
W. Priebe
,
O. Varela
The Journal of antibiotics
1984
Corpus ID: 46512905
3'-Deamino-4'-epi-3'-hydroxy-daunorubicin (11) and -doxorubicin (14) have been synthesized. In the in vivo murine P-388…
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