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3'-deamino-3'-hydroxydoxorubicin

Known as: 3-DHD, 5,12-Naphthacenedione, 10-((2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-, hydroxyrubicin 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

EpirubicinTopoisomerase II Inhibitors
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
N-Benzyladriamycin-14-valerate (AD 198): A Non-Cardiotoxic Anthracycline That Is Cardioprotective through PKC-ϵ Activation
N-Benzyladriamycin-14-valerate (AD 198) is one of several novel anthracycline protein kinase C (PKC)-activating agents developed… Expand
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2001
2001
Drug sequestration in cytoplasmic organelles does not contribute to the diminished sensitivity of anthracyclines in multidrug resistant K562 cells.
Cells that acquire multidrug resistance (MDR) are characterized by a decreased accumulation of a variety of drugs. In addition… Expand
Highly Cited
2000
Highly Cited
2000
Inhibition of the P-glycoprotein- and multidrug resistance protein-mediated efflux of anthracyclines and calceinacetoxymethyl ester by PAK-104P.
Multidrug resistance phenotype in mammalian cells is often correlated with overexpression of P-glycoprotein or Multidrug… Expand
Highly Cited
1997
Highly Cited
1997
Electrostatic and non-electrostatic contributions to the binding free energies of anthracycline antibiotics to DNA.
The knowledge about molecular factors driving simple ligand-DNA interactions is still limited. The aim of the present study was… Expand
1994
1994
P‐glycoprotein‐mediated efflux of hydroxyrubicin, a neutral anthracycline derivative, in resistant K562 cells
Hydroxyrubin (OH‐Dox), a neutral doxorubicin derivative that is only slightly cross‐resistant to doxorubicin (Dox), can be… Expand
1994
1994
Hydroxyrubicin, a deaminated derivative of doxorubicin, inhibits mammalian DNA topoisomerase II and partially circumvents multidrug resistance
In vivo effectiveness of doxorubicin remains restricted due to toxicity and drug resistance. Hydroxyrubicin is a synthetic analog… Expand
Highly Cited
1993
Highly Cited
1993
Removal of the basic center from doxorubicin partially overcomes multidrug resistance and decreases cardiotoxicity
Hydroxyrubicin, a synthetic doxorubicin analog in which the basic amino group at C-3' is replaced by a hydroxyl group, was used… Expand
1993
1993
Intrinsic cytotoxicity and reversal of multidrug-resistance by monensin in kb parent and mdr cells.
Results presented in this study indicate that monensin, a Na+/H+ gradient ionophore, is by itself a potent inhibitor of… Expand
1984
1984
3'-Deamino-4'-epi-3'-hydroxy-daunorubicin and -doxorubicin. Synthesis and antitumor activity.
3'-Deamino-4'-epi-3'-hydroxy-daunorubicin (11) and -doxorubicin (14) have been synthesized. In the in vivo murine P-388… Expand
1984
1984
Synthesis and antitumor activity of 3'-deamino-3'-hydroxydoxorubicin. A facile procedure for the preparation of doxorubicin analogs.
Two successful routes have been developed for preparation of 3'-deamino-3'-hydroxydoxorubicin (11), based on protection of the 14… Expand
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