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3',5'-dichloromethotrexate

Known as: Dichloroamethopterin, 3',5'-Dichloroamethopterin, N-[3,5-Dichloro-4-[(2,4-diamino-6-pteridinylmethyl)methylamino]benzoyl] Glutamic Acid 
A chlorinated methotrexate derivative. Dichloromethotrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine… 
National Institutes of Health

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5 relations

Broader (3)

Antineoplastic AgentsFolic Acid AntagonistsMethotrexate

Narrower (1)

NSC 29630
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1994
1994
Chronic in vivo evaluation of an electrohydraulic total artificial heart.
Development of the Abiomed total artificial heart (TAH) designed for human use is progressing. Implant durations of longer than… 
1990
1990
Correlation of loss of activity of human aldehyde dehydrogenase with reaction of bromoacetophenone with glutamic acid-268 and cysteine-302 residues. Partial-sites reactivity of aldehyde dehydrogenase…
Bromoacetophenone (2-bromo-1-phenylethanone) has been characterized as an affinity reagent for human aldehyde dehydrogenase (EC 1… 
1987
1987
Relationship between hepatotoxicity and induction of replicative DNA synthesis following single or multiple doses of carbon tetrachloride.
The in vivo-in vitro DNA repair and DNA replication assay in mouse hepatocytes has promise as a short-term test for detecting… 
1986
1986
Parathyroid hormone effect on the fragility of human young and old red blood cells in uremia.
Parathyroid hormone (PTH) is elevated in patients with chronic renal failure (CRF) and was suggested to be one of the factors… 
Highly Cited
1984
Highly Cited
1984
Pharmacokinetics of etoposide (VP16) in children and adolescents with refractory solid tumors.
The clinical pharmacokinetics of etoposide were studied in eight pediatric patients with refractory solid tumors. The alpha-phase… 
1981
1981
Biochemical evaluation of riboflavin and vitamin B6 status of institutionalized and non-institutionalized elderly in Central Kentucky.
A study was conducted to assess the nutritional status of riboflavin and vitamin B6 of the elderly in Central Kentucky. Elderly… 
1969
1969
Serum enzyme patterns in acute poisoning with organochlorine insecticides.
The effect of the administration of single, oral, convulsive doses of DDT, aldrin, dieldrin, or endrin on the activity of… 
Highly Cited
1958
Highly Cited
1958
The disappearance rate of glutamic oxalacetic transaminase from the circulation and its distribution in the body's fluid compartments and secretions.
T HE release of glutamic oxalacetic transaminase (GOT) from damaged tissues and the significance of serum GOT levels as an index… 
1954
1954
The utilization and formation of dicarboxylic amino acids by cell suspensions of normal and malignant lymphatic tissues.
Summary Cell suspensions of rabbit appendix, rat thymus, mouse spleen, and two mouse lymphosarcomas were incubated with acetate-2… 
Review
1948
Review
1948
Glutamine-synthesizing System of Staphylococcus aureus: Its Inhibition by Crystal Violet and Methionine-sulphoxide
IN the course of studies on the assimilation of glutamic acid by Gram-positive cocci, it has been shown that dyes of the…