27-hydroxycholesterol

Known as: 27HC, 27OHC, (25R)-Cholest-5-Ene-3beta,26-Diol 
An endogenous metabolite of cholesterol produced by the hydroxylation of the carbon at position 27 by the enzyme sterol 26-hydroxylase, mitochondrial… (More)
National Institutes of Health

Papers overview

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2014
2014
Oxysterols are cholesterol metabolites that serve multiple functions in lipid metabolism, including as liver X receptor (LXR… (More)
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Highly Cited
2013
Highly Cited
2013
Hypercholesterolemia is a risk factor for estrogen receptor (ER)-positive breast cancers and is associated with a decreased… (More)
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Highly Cited
2013
Highly Cited
2013
To date, estrogen is the only known endogenous estrogen receptor (ER) ligand that promotes ER+ breast tumor growth. We report… (More)
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Highly Cited
2008
Highly Cited
2008
Selective estrogen receptor (ER) modulators (SERMs) are ER ligands whose relative agonist/antagonist activities vary in a cell… (More)
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Highly Cited
2007
Highly Cited
2007
The cardioprotective effects of estrogen are mediated by receptors expressed in vascular cells. Here we show that 27… (More)
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Highly Cited
2005
Highly Cited
2005
Side chain oxidized oxysterols have a unique ability to traverse lipophilic membranes. We tested the hypothesis that there is a… (More)
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Highly Cited
2001
Highly Cited
2001
The nuclear receptors liver X receptor alpha (LXRalpha) (NR1H3) and LXRbeta (NR1H2) are important regulators of genes involved in… (More)
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Highly Cited
2001
Highly Cited
2001
The major cholesterol oxidation products in the human circulation are 27-hydroxycholesterol, 24-hydroxycholesterol, and 7alpha… (More)
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Highly Cited
1997
Highly Cited
1997
Cultured macrophages and endothelial cells have been reported to secrete 27-oxygenated metabolites of cholesterol. This mechanism… (More)
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Highly Cited
1994
Highly Cited
1994
27-Hydroxycholesterol was found in surprisingly high amounts in atherosclerotic human femoral arteries. When human macrophages… (More)
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