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27-hydroxycholesterol

Known as: 27HC, 27OHC, (25R)-Cholest-5-Ene-3beta,26-Diol 
An endogenous metabolite of cholesterol produced by the hydroxylation of the carbon at position 27 by the enzyme sterol 26-hydroxylase, mitochondrial… 
National Institutes of Health

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Broader (1)

Hydroxycholesterols

Papers overview

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2017
2017
Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis
Nguyen, V. T.M., Barozzi, I., Faronata, M., Lombardo, Y., Steel, J. H., Patel, N., Darbre, P., Castellano, L., Gyorffy, B… 
2016
2016
Evidence of pomegranate methanolic extract in antagonizing the endogenous SERM, 27‐hydroxycholesterol
The direct relationship between obesity and breast cancer has been elucidated recently with the identification of a cholesterol… 
2015
2015
Hydroxycholesterol upregulates CD 14 and predisposes monocytic cells to superproduction of CCL 2 in response to lipopolysaccharide
Abbreviations: ERK, extracellular-signal-regulated k smoothmuscle cells; 27OHChol, 27-hydroxycholesterol; L membrane-associated… 
2013
2013
Characterization of Cholesterol Homeostasis in Telomerase-immortalized Tangier Disease Fibroblasts Reveals Marked Phenotype Variability*
Background: The reason for the variability in degree of atherosclerosis in Tangier disease remains poorly understood. Results… 
2010
2010
Abstract 18427: 27-Hydroxycholesterol, the First Identified endogenous SERM, Promotes Atherogenesis in Mice
Estrogen has important impact on cardiovascular health, and in mice estrogen actions mediated by estrogen receptor (ER) α prevent… 
2009
2009
The Effect of Estrogen Depletion on Skeletal Muscle Metabolism
Additional contributors: Sarah Greising; Susan Novotny; Jarrod Call; Kristen Baltgalvis; Dawn A. Lowe (faculty mentor). 
2005
2005
Cholesterol homeostasis in human brain : Evidence for an age-dependent flux of 24 S-hydroxycholesterol from the brain into the circulation ( cerebrospinal fluid / oxysterols / plasma / stable…
We have investigated whether side chainhydroxylated cholesterol species are important for elimination of cholesterol from the… 
2002
2002
Inhibitors of sterol synthesis . Chemical synthesis , structure , and biological activities of ( 25 R )-3 & 26-di hydroxy-5 ~-cholest-8 ( 14 )-en-15-one , a metabdlite of 3 P-hydroxy-5 ~ ~-c holest-8…
3P-Hydroxy-5a-cholest-8(14)-en-15-one (I) is a potent inhibitor of sterol synthesis with significant hypocholesterolemic activity… 
2000
2000
7 b-Hydroxycholesterol induces Ca 2 + oscillations , MAP kinase activation and apoptosis in human aortic smooth muscle cells
In the present study, we characterize the early cytotoxic effects of 7b-hydroxycholesterol, a major cytotoxin in oxidized LDL, in… 
1994
1994
Selective inhibition of mammalian lanosterol 14 alpha-demethylase by RS-21607 in vitro and in vivo.
The discovery of selective lanosterol 14 alpha-demethylase inhibitors may lead to novel hypolipidemic drugs. RS-21607, (2S,4S…