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25-hydroxycholesterol 7alpha-hydroxylase activity

Known as: cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity, CYP7B1 oxysterol 7alpha-hydroxylase activity, CYP7B1 
Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O, and cholest-5-ene… Expand
National Institutes of Health

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CYP7B1 protein, human

Papers overview

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Highly Cited
2012
Highly Cited
2012
Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses.
7α,25-dihydroxycholesterol (7α,25-OHC) is a ligand for the G protein-coupled receptor EBI2; however, the cellular sources of this… Expand
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2010
2010
Effects of CYP7B1-mediated catalysis on estrogen receptor activation.
Most of the many biological effects of estrogens are mediated via the estrogen receptors ERalpha and beta. The current study… Expand
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2009
2009
CYP7B1-mediated metabolism of 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol): a novel pathway for potential regulation of the cellular levels of androgens and neurosteroids.
The current study presents data indicating that 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol) undergoes a previously… Expand
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Highly Cited
2008
Highly Cited
2008
Hepatic insulin resistance directly promotes formation of cholesterol gallstones
Despite the well-documented association between gallstones and the metabolic syndrome, the mechanistic links between these two… Expand
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2008
2008
Hepatic insulin resistance ties cholesterol gallstone formation and the metabolic syndrome.
AbstractBiddinger SB, Haas JT, Yu BB, Bezy O, Jing E, ZhangW, Unterman TG, Carey MC, Kahn CR. Hepatic insu-lin resistance… Expand
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2006
2006
Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells.
The present study reports effects of androgens and estrogens on human CYP7B1 transcription in prostate cancer LNCaP cells… Expand
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2006
2006
Inter-conversion of 7alpha- and 7beta-hydroxy-dehydroepiandrosterone by the human 11beta-hydroxysteroid dehydrogenase type 1.
The dehydroepiandrosterone (DHEA) 7alpha-hydroxylation in humans takes place in the liver, skin, and brain. These organs are… Expand
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2004
2004
The Pathogenesis of Atherosclerosis Effects of infection and inflammation on lipid and lipoprotein metabolism : mechanisms and consequences to the host 1
Infection and inflammation induce the acutephase response (APR), leading to multiple alterations in lipid and lipoprotein… Expand
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2003
2003
Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat.
Cholesterol metabolized to 7alpha-hydroxylated bile acids is a principle pathway of cholesterol degradation. Cholesterol 7alpha… Expand
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2002
2002
Expression of key enzymes in bile acid biosynthesis during development: CYP7B1-mediated activities show tissue-specific differences.
The developmental variation of cytochrome P450 (CYP)7A1, CYP7B1, CYP27A1, and 3beta-hydroxy-Delta(5)-C(27)-steroid dehydrogenase… Expand
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