FAQ

25-hydroxycholesterol 7alpha-hydroxylase activity

Known as: cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity, CYP7B1 oxysterol 7alpha-hydroxylase activity, CYP7B1 
Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O, and cholest-5-ene… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2002-2017
01220022017

Related topics

Related topics

1 relation
CYP7B1 protein, human

Related mentions per year

Related mentions per year

1996-2017
1990200020102020
25-hydroxycholesterol 7alpha-hydroxylase activity
CYP7B1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 and 7α-Hydroxylase CYP7B1 during Social Stress
11β-hydroxysteroid dehydrogenase type 1 (11HSD1) is an enzyme that amplifies intracellular glucocorticoid concentration by the… (More)
  • table 1
  • figure 2
  • figure 3
  • table 2
  • figure 4
Is this relevant?
Highly Cited
2012
Highly Cited
2012
Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses.
7α,25-dihydroxycholesterol (7α,25-OHC) is a ligand for the G protein-coupled receptor EBI2; however, the cellular sources of this… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2009
2009
CYP7B1-mediated metabolism of 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol): a novel pathway for potential regulation of the cellular levels of androgens and neurosteroids.
The current study presents data indicating that 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol) undergoes a previously… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Hepatic insulin resistance directly promotes formation of cholesterol gallstones
Despite the well-documented association between gallstones and the metabolic syndrome, the mechanistic links between these two… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2008
2008
Hepatic insulin resistance ties cholesterol gallstone formation and the metabolic syndrome.
Despite the well-documented association between gallstones and the metabolic syndrome,1,2 the mechanistic links between these two… (More)
Is this relevant?
2006
2006
Inter-conversion of 7alpha- and 7beta-hydroxy-dehydroepiandrosterone by the human 11beta-hydroxysteroid dehydrogenase type 1.
The dehydroepiandrosterone (DHEA) 7alpha-hydroxylation in humans takes place in the liver, skin, and brain. These organs are… (More)
Is this relevant?
2006
2006
Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells.
The present study reports effects of androgens and estrogens on human CYP7B1 transcription in prostate cancer LNCaP cells… (More)
Is this relevant?
2004
2004
The Pathogenesis of Atherosclerosis Effects of infection and inflammation on lipid and lipoprotein metabolism : mechanisms and consequences to the host 1
Infection and inflammation induce the acutephase response (APR), leading to multiple alterations in lipid and lipoprotein… (More)
  • table 1
  • figure 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
2003
2003
Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat.
Cholesterol metabolized to 7alpha-hydroxylated bile acids is a principle pathway of cholesterol degradation. Cholesterol 7alpha… (More)
Is this relevant?
2002
2002
Expression of key enzymes in bile acid biosynthesis during development: CYP7B1-mediated activities show tissue-specific differences.
The developmental variation of cytochrome P450 (CYP)7A1, CYP7B1, CYP27A1, and 3beta-hydroxy-Delta(5)-C(27)-steroid dehydrogenase… (More)
Is this relevant?