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24-hydroxycholesterol 7alpha-hydroxylase activity

Known as: CYP39A1 oxysterol 7alpha-hydroxylase activity, 24-hydroxycholesterol 7alpha-monooxygenase activity, (24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity 
Catalysis of the reaction: (24R)-cholest-5-ene-3beta,24-diol + H(+) + NADPH + O(2) = (24R)-7alpha,24-dihydroxycholesterol + H(2)O + NADP(+). [EC:1.14… 
National Institutes of Health

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Review
2005
Review
2005
Purpose: The cytochromes P450 are a multigene family of enzymes with a central role in the oxidative metabolism of a wide range…