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2-pyrrolino-DOX

Known as: 2-pyrrolinodoxorubicin, 3'-deamino-3'-(2''-pyrroline-1''-yl)doxorubicin trifluoroacetate 
 
National Institutes of Health

Papers overview

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2006
2006
Highly potent and novel derivatives of doxorubicin were linked to monoclonal antibodies (mAbs) for site-specific drug delivery… Expand
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2006
2006
The aim of this study was to investigate the effect of treatment of experimental ovarian cancers with targeted cytotoxic analogs… Expand
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2004
2004
Receptor targeted chemotherapy is less toxic and more effective than conventional chemotherapy. Receptors for luteinizing hormone… Expand
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2000
2000
A highly potent derivative of doxorubicin, 2-pyrrolinodoxorubicin (AN-201), was linked to [D-Lys6]luteinizing hormone-releasing… Expand
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Highly Cited
1999
Highly Cited
1999
We evaluated whether AN-238, the cytotoxic analogue of somatostatin (SST) consisting of the radical 2-pyrrolinodoxorubicin (AN… Expand
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1999
1999
Receptors for luteinizing hormone–releasing hormone (LH‐RH) are found in about 50% of human breast carcinomas. A highly potent… Expand
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1999
1999
SummaryRecently, we developed a powerful cytotoxic analogue of bombesin AN-215, in which the bombesin-like carrier peptide Gln… Expand
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Highly Cited
1998
Highly Cited
1998
Receptors for somatostatin (SST) that are found on prostate cancers might be used for targeting of chemotherapeutic agents. Thus… Expand
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Highly Cited
1997
Highly Cited
1997
Recently, we developed a targeted cytotoxic analog AN-207 of luteinizing hormone-releasing hormone (LH-RH), consisting of an… Expand
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Highly Cited
1996
Highly Cited
1996
A convenient, high yield conversion of doxorubicin to 3'-deamino-3'-(2''-pyrroline-1''-yl)doxorubicin is described. This… Expand
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