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2-pyrrolino-DOX

Known as: 2-pyrrolinodoxorubicin, 3'-deamino-3'-(2''-pyrroline-1''-yl)doxorubicin trifluoroacetate 
National Institutes of Health

Papers overview

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Review
2008
Review
2008
  • A. Schally
  • Hormone and metabolic research = Hormon- und…
  • 2008
  • Corpus ID: 42943864
The discovery of hypothalamic hormones was briefly reviewed. The development of new hormonal methods for the therapy of various… Expand
2006
2006
Highly potent and novel derivatives of doxorubicin were linked to monoclonal antibodies (mAbs) for site-specific drug delivery… Expand
Review
2000
Review
2000
The use of peptide analogs in the therapy of prostate cancer is reviewed. The preferred primary treatment of advanced androgen… Expand
Highly Cited
2000
Highly Cited
2000
The effectiveness of chemotherapy targeted to bombesin (BN) receptors was evaluated in nude mice bearing PC‐3 human androgen… Expand
Highly Cited
1999
Highly Cited
1999
We evaluated whether AN-238, the cytotoxic analogue of somatostatin (SST) consisting of the radical 2-pyrrolinodoxorubicin (AN… Expand
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1999
1999
Receptors for luteinizing hormone–releasing hormone (LH‐RH) are found in about 50% of human breast carcinomas. A highly potent… Expand
1999
1999
SummaryRecently, we developed a powerful cytotoxic analogue of bombesin AN-215, in which the bombesin-like carrier peptide Gln… Expand
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Highly Cited
1998
Highly Cited
1998
To create cytotoxic hybrid analogs of somatostatin (SST), octapeptides RC-160 (D-Phe-Cys-Tyr-D-Trp- Lys-Val-Cys-Trp-NH2) and RC… Expand
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Highly Cited
1996
Highly Cited
1996
A convenient, high yield conversion of doxorubicin to 3'-deamino-3'-(2''-pyrroline-1''-yl)doxorubicin is described. This… Expand
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Highly Cited
1996
Highly Cited
1996
Doxorubicin (DOX) and its daunosamine-modified derivative, 2-pyrrolino-DOX, which is 500-1000 times more active than DOX, were… Expand