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2-propyl-4-pentenoic acid
Known as:
4-en-VPA
, 4-ene VPA
, 4-ene valproic acid
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Fatty Acids, Monounsaturated
Teratogens
Narrower (1)
delta(4)-VPA
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Quantification of valproic acid and its metabolite 2-propyl-4-pentenoic acid in human plasma using HPLC-MS/MS.
Hao Cheng
,
Zhongfa Liu
,
+5 authors
K. Chan
Journal of chromatography. B, Analytical…
2007
Corpus ID: 25038137
2000
2000
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
S. Kumar
,
H. Wong
,
S. A. Yeung
,
K. Riggs
,
F. Abbott
,
D. Rurak
Drug Metabolism And Disposition
2000
Corpus ID: 737653
Metabolism and renal excretion of valproic acid (VPA) were examined in maternal, fetal, and newborn sheep to identify the…
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1997
1997
A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its alpha-fluorinated analogue: phase II metabolism and pharmacokinetics.
Wei Tang
,
Frank S. Abbott
Drug Metabolism And Disposition
1997
Corpus ID: 19301562
An earlier study in rats revealed that alpha-fluorination of 2-propyl-4-pentenoic acid (4-ene VPA), a toxic metabolite of the…
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Highly Cited
1995
Highly Cited
1995
Fluorinated analogues as mechanistic probes in valproic acid hepatotoxicity: hepatic microvesicular steatosis and glutathione status.
W. Tang
,
A. Borel
,
T. Fujimiya
,
F. Abbott
Chemical Research in Toxicology
1995
Corpus ID: 23983638
It is postulated that the hepatotoxicity of valproic acid (VPA) results from the mitochondrial beta-oxidation of its cytochrome…
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1994
1994
Comparative toxicity of valproic acid and its metabolites in liver slices from adult rats, weanling rats and humans.
R. Fisher
,
J. T. Sanuik
,
H. Nau
,
A. Gandolfi
,
K. Brendel
Toxicology in Vitro
1994
Corpus ID: 11814190
1992
1992
Is 2‐Propyl‐4‐Pentenoic Acid, a Hepatotoxic Metabolite of Valproate, Responsible for Valproate‐Induced Hyperammonemia?
T. Kondo
,
M. Ishida
,
+8 authors
H. Kudo
Epilepsia
1992
Corpus ID: 22385800
Summary: To investigate the association between valproate metabolism (VPA) and VPA‐induced hyperammonemia together with the…
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Highly Cited
1991
Highly Cited
1991
Identification and characterization of the glutathione and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, in rats and humans.
K. Kassahun
,
K. Farrell
,
F. Abbott
Drug Metabolism And Disposition
1991
Corpus ID: 23449542
The severe hepatotoxicity of valproic acid (VPA) is believed to be mediated through reactive metabolites. The formation of…
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Highly Cited
1990
Highly Cited
1990
Effects of polytherapy with phenytoin, carbamazepine, and stiripentol on formation of 4‐ene‐valproate, a hepatotoxic metabolite of valproic acid
R. Levy
,
A. Rettenmeier
,
+7 authors
Pierre Loiseau
Clinical pharmacology and therapy
1990
Corpus ID: 30613118
The incidence of valproic acid hepatotoxicity has been reported to increase in patients who are receiving polytherapy. A minor…
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1988
1988
Pharmacokinetic aspects of drug effects in vitro (II) placental transfer to the embryo and activity of some carboxylic acids structurally related to valproic acid in whole embryos in culture.
H. Nau
,
C. Lewandowski
,
S. Klug
,
D. Neubert
Toxicology in Vitro
1988
Corpus ID: 23278131
Highly Cited
1981
Highly Cited
1981
Valproic acid and several metabolites: quantitative determination in serum, urine, breast milk and tissues by gas chromatography-mass spectrometry using selected ion monitoring.
H. Nau
,
W. Wittfoht
,
H. Schäfer
,
C. Jakobs
,
D. Rating
,
H. Helge
Journal of Chromatography A
1981
Corpus ID: 42698538
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