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2-keto-4-methylvalerate

Known as: ketoleucine, 2-ketoisocaproate, alpha-ketoisocaproate 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

alpha-ketoisocaproic acid

Papers overview

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Highly Cited
2015
Highly Cited
2015
Urinary metabolic signatures of human adiposity
In a large-scale population-based metabolic phenotyping study, diverse sets of urinary metabolites, including gut microbial co… 
Highly Cited
2014
Highly Cited
2014
Metabolite and peptide levels in plasma and CSF differentiating healthy controls from patients with newly diagnosed Parkinson's disease.
BACKGROUND Parkinson's disease (PD) is a progressive, multi-focal neurodegenerative disease for which there is no effective… 
Highly Cited
2010
Highly Cited
2010
Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women
Insulin resistance progressing to type 2 diabetes mellitus (T2DM) is marked by a broad perturbation of macronutrient intermediary… 
Highly Cited
2008
Highly Cited
2008
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
The risk determinants of type 1 diabetes, initiators of autoimmune response, mechanisms regulating progress toward β cell failure… 
Highly Cited
2002
Highly Cited
2002
Reduction in Pancreatic Transcription Factor PDX-1 Impairs Glucose-stimulated Insulin Secretion*
Complete lack of transcription factor PDX-1 leads to pancreatic agenesis, whereas heterozygosity for PDX-1 mutations has been… 
Highly Cited
1993
Highly Cited
1993
Glucose Sensitivity of ATP-Sensitive K+ Channels Is Impaired in β-Cells of the GK Rat: A New Genetic Model of NIDDM
In the Goto-Kakizaki rat, a new genetic model of NIDDM, insulin response to glucose is selectively impaired. To elucidate the… 
Highly Cited
1990
Highly Cited
1990
Single islet beta‐cell stimulation by nutrients: relationship between pyridine nucleotides, cytosolic Ca2+ and secretion.
It is generally believed that the initiation of insulin secretion by nutrient stimuli necessitates the generation of metabolic… 
Highly Cited
1987
Highly Cited
1987
Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. Evidence for distinct mechanisms in regulation of net amino acid deposition.
The effects of physiologic hyperinsulinemia and hyperaminoacidemia, alone or in combination, on leucine kinetics in vivo were… 
Highly Cited
1979
Highly Cited
1979
Leucine degradation in cell-free extracts of skeletal muscle.
Since skeletal muscle is the major site in the body for oxidation of leucine, isoleucine and valine, the pathway and control of… 
Highly Cited
1978
Highly Cited
1978
The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function.
1. In isolated pancreatic islets, pyruvate causes a shift to the left of the sigmoidal curve relating the rate of insulin release… 
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