2-keto-4-methylvalerate

Known as: ketoleucine, 2-ketoisocaproate, alpha-ketoisocaproate 
 
National Institutes of Health

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Broader (1)

alpha-ketoisocaproic acid

Papers overview

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2015
2015
Urinary metabolic signatures of human adiposity
Obesity is a major public health problem worldwide. We used 24-hour urinary metabolic profiling by proton (1H) nuclear magnetic… (More)
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Highly Cited
2010
Highly Cited
2010
Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women
Insulin resistance progressing to type 2 diabetes mellitus (T2DM) is marked by a broad perturbation of macronutrient intermediary… (More)
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Highly Cited
2008
Highly Cited
2008
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
The risk determinants of type 1 diabetes, initiators of autoimmune response, mechanisms regulating progress toward beta cell… (More)
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Highly Cited
2002
Highly Cited
2002
Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion.
Complete lack of transcription factor PDX-1 leads to pancreatic agenesis, whereas heterozygosity for PDX-1 mutations has been… (More)
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1994
1994
Insulinotropic action of AICA riboside. I. Insulin release by isolated islets and the perfused pancreas.
AICA riboside (0.1 to 1.0mM) caused a concentration-related increase of insulin output caused by D-glucose (5.6 to 20.0mM) in… (More)
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1993
1993
Glucose sensitivity of ATP-sensitive K+ channels is impaired in beta-cells of the GK rat. A new genetic model of NIDDM.
In the Goto-Kakizaki rat, a new genetic model of NIDDM, insulin response to glucose is selectively impaired. To elucidate the… (More)
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1992
1992
Control of insulin gene expression by glucose.
Northern-blot analysis was used to demonstrate that an increase in extracellular glucose concentration increased the content of… (More)
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Highly Cited
1990
Highly Cited
1990
Single islet beta-cell stimulation by nutrients: relationship between pyridine nucleotides, cytosolic Ca2+ and secretion.
It is generally believed that the initiation of insulin secretion by nutrient stimuli necessitates the generation of metabolic… (More)
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1987
1987
Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. Evidence for distinct mechanisms in regulation of net amino acid deposition.
The effects of physiologic hyperinsulinemia and hyperaminoacidemia, alone or in combination, on leucine kinetics in vivo were… (More)
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1984
1984
Specificity of the effects of leucine and its metabolites on protein degradation in skeletal muscle.
The effects of leucine, its metabolites, and the 2-oxo acids of valine and isoleucine on protein synthesis and degradation in… (More)
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