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2-keto-4-methylvalerate

Known as: ketoleucine, 2-ketoisocaproate, alpha-ketoisocaproate 
 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
In a large-scale population-based metabolic phenotyping study, diverse sets of urinary metabolites, including gut microbial co… Expand
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Highly Cited
2010
Highly Cited
2010
Insulin resistance progressing to type 2 diabetes mellitus (T2DM) is marked by a broad perturbation of macronutrient intermediary… Expand
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Highly Cited
2008
Highly Cited
2008
The risk determinants of type 1 diabetes, initiators of autoimmune response, mechanisms regulating progress toward β cell failure… Expand
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Highly Cited
2002
Highly Cited
2002
Complete lack of transcription factor PDX-1 leads to pancreatic agenesis, whereas heterozygosity for PDX-1 mutations has been… Expand
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Highly Cited
2002
Highly Cited
2002
The effect of the supply of metabolizable protein (MP) on protein metabolism across the splanchnic tissues was determined in six… Expand
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Highly Cited
1993
Highly Cited
1993
In the Goto-Kakizaki rat, a new genetic model of NIDDM, insulin response to glucose is selectively impaired. To elucidate the… Expand
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Highly Cited
1992
Highly Cited
1992
Northern-blot analysis was used to demonstrate that an increase in extracellular glucose concentration increased the content of… Expand
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Highly Cited
1990
Highly Cited
1990
It is generally believed that the initiation of insulin secretion by nutrient stimuli necessitates the generation of metabolic… Expand
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Highly Cited
1987
Highly Cited
1987
The effects of physiologic hyperinsulinemia and hyperaminoacidemia, alone or in combination, on leucine kinetics in vivo were… Expand
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Highly Cited
1978
Highly Cited
1978
1. In isolated pancreatic islets, pyruvate causes a shift to the left of the sigmoidal curve relating the rate of insulin release… Expand
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