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2-keto-4-methylvalerate

Known as: ketoleucine, 2-ketoisocaproate, alpha-ketoisocaproate 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
In a large-scale population-based metabolic phenotyping study, diverse sets of urinary metabolites, including gut microbial co… Expand
Highly Cited
2010
Highly Cited
2010
Insulin resistance progressing to type 2 diabetes mellitus (T2DM) is marked by a broad perturbation of macronutrient intermediary… Expand
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Highly Cited
2008
Highly Cited
2008
The risk determinants of type 1 diabetes, initiators of autoimmune response, mechanisms regulating progress toward β cell failure… Expand
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Highly Cited
2002
Highly Cited
2002
Complete lack of transcription factor PDX-1 leads to pancreatic agenesis, whereas heterozygosity for PDX-1 mutations has been… Expand
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Highly Cited
1993
Highly Cited
1993
In the Goto-Kakizaki rat, a new genetic model of NIDDM, insulin response to glucose is selectively impaired. To elucidate the… Expand
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Highly Cited
1990
Highly Cited
1990
It is generally believed that the initiation of insulin secretion by nutrient stimuli necessitates the generation of metabolic… Expand
Highly Cited
1987
Highly Cited
1987
The effects of physiologic hyperinsulinemia and hyperaminoacidemia, alone or in combination, on leucine kinetics in vivo were… Expand
Highly Cited
1983
Highly Cited
1983
In the presence of Li+, glucose, 2-ketoisocaproate and carbamylcholine induced the rapid formation of 3H-inositol phosphates in… Expand
Highly Cited
1979
Highly Cited
1979
Since skeletal muscle is the major site in the body for oxidation of leucine, isoleucine and valine, the pathway and control of… Expand
Highly Cited
1978
Highly Cited
1978
1. In isolated pancreatic islets, pyruvate causes a shift to the left of the sigmoidal curve relating the rate of insulin release… Expand
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