2-keto-4-methylvalerate

In a large-scale population-based metabolic phenotyping study, diverse sets of urinary metabolites, including gut microbial co… Expand

Insulin resistance progressing to type 2 diabetes mellitus (T2DM) is marked by a broad perturbation of macronutrient intermediary… Expand

The risk determinants of type 1 diabetes, initiators of autoimmune response, mechanisms regulating progress toward β cell failure… Expand

Complete lack of transcription factor PDX-1 leads to pancreatic agenesis, whereas heterozygosity for PDX-1 mutations has been… Expand

The effect of the supply of metabolizable protein (MP) on protein metabolism across the splanchnic tissues was determined in six… Expand

In the Goto-Kakizaki rat, a new genetic model of NIDDM, insulin response to glucose is selectively impaired. To elucidate the… Expand

Northern-blot analysis was used to demonstrate that an increase in extracellular glucose concentration increased the content of… Expand

It is generally believed that the initiation of insulin secretion by nutrient stimuli necessitates the generation of metabolic… Expand

The effects of physiologic hyperinsulinemia and hyperaminoacidemia, alone or in combination, on leucine kinetics in vivo were… Expand

1. In isolated pancreatic islets, pyruvate causes a shift to the left of the sigmoidal curve relating the rate of insulin release… Expand