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2-keto-4-methylvalerate
Known as:
ketoleucine
, 2-ketoisocaproate
, alpha-ketoisocaproate
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National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
alpha-ketoisocaproic acid
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Urinary metabolic signatures of human adiposity
P. Elliott
,
J. Posma
,
+11 authors
J. Nicholson
Science Translational Medicine
2015
Corpus ID: 25089054
In a large-scale population-based metabolic phenotyping study, diverse sets of urinary metabolites, including gut microbial co…
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Highly Cited
2014
Highly Cited
2014
Metabolite and peptide levels in plasma and CSF differentiating healthy controls from patients with newly diagnosed Parkinson's disease.
M. Trupp
,
P. Jonsson
,
+9 authors
L. Forsgren
Journal of Parkinson's Disease
2014
Corpus ID: 39985212
BACKGROUND Parkinson's disease (PD) is a progressive, multi-focal neurodegenerative disease for which there is no effective…
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Highly Cited
2010
Highly Cited
2010
Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women
O. Fiehn
,
W. Garvey
,
J. Newman
,
K. Lok
,
C. Hoppel
,
S. Adams
PLoS ONE
2010
Corpus ID: 18609065
Insulin resistance progressing to type 2 diabetes mellitus (T2DM) is marked by a broad perturbation of macronutrient intermediary…
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Highly Cited
2008
Highly Cited
2008
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
M. Orešič
,
S. Simell
,
+19 authors
O. Simell
Journal of Experimental Medicine
2008
Corpus ID: 6242371
The risk determinants of type 1 diabetes, initiators of autoimmune response, mechanisms regulating progress toward β cell failure…
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Highly Cited
2002
Highly Cited
2002
Reduction in Pancreatic Transcription Factor PDX-1 Impairs Glucose-stimulated Insulin Secretion*
M. Brissova
,
M. Shiota
,
+5 authors
A. Powers
Journal of Biological Chemistry
2002
Corpus ID: 25660333
Complete lack of transcription factor PDX-1 leads to pancreatic agenesis, whereas heterozygosity for PDX-1 mutations has been…
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Highly Cited
1993
Highly Cited
1993
Glucose Sensitivity of ATP-Sensitive K+ Channels Is Impaired in β-Cells of the GK Rat: A New Genetic Model of NIDDM
Y. Tsuura
,
H. Ishida
,
+6 authors
Y. Seino
Diabetes
1993
Corpus ID: 29561796
In the Goto-Kakizaki rat, a new genetic model of NIDDM, insulin response to glucose is selectively impaired. To elucidate the…
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Highly Cited
1990
Highly Cited
1990
Single islet beta‐cell stimulation by nutrients: relationship between pyridine nucleotides, cytosolic Ca2+ and secretion.
W. Pralong
,
C. Bartley
,
C. Wollheim
EMBO Journal
1990
Corpus ID: 341178
It is generally believed that the initiation of insulin secretion by nutrient stimuli necessitates the generation of metabolic…
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Highly Cited
1987
Highly Cited
1987
Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. Evidence for distinct mechanisms in regulation of net amino acid deposition.
P. Tessari
,
S. Inchiostro
,
+6 authors
G. Crepaldi
Journal of Clinical Investigation
1987
Corpus ID: 272439
The effects of physiologic hyperinsulinemia and hyperaminoacidemia, alone or in combination, on leucine kinetics in vivo were…
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Highly Cited
1979
Highly Cited
1979
Leucine degradation in cell-free extracts of skeletal muscle.
R. Odessey
,
A. Goldberg
Biochemical Journal
1979
Corpus ID: 22349811
Since skeletal muscle is the major site in the body for oxidation of leucine, isoleucine and valine, the pathway and control of…
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Highly Cited
1978
Highly Cited
1978
The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function.
A. Sener
,
S. Kawazu
,
+5 authors
W. Malaisse
Biochemical Journal
1978
Corpus ID: 24578058
1. In isolated pancreatic islets, pyruvate causes a shift to the left of the sigmoidal curve relating the rate of insulin release…
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