2-keto-4-methylvalerate

Known as: ketoleucine, 2-ketoisocaproate, alpha-ketoisocaproate 
 
National Institutes of Health

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2015
2015
Obesity is a major public health problem worldwide. We used 24-hour urinary metabolic profiling by proton (1H) nuclear magnetic… (More)
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Highly Cited
2010
Highly Cited
2010
Insulin resistance progressing to type 2 diabetes mellitus (T2DM) is marked by a broad perturbation of macronutrient intermediary… (More)
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Highly Cited
2008
Highly Cited
2008
The risk determinants of type 1 diabetes, initiators of autoimmune response, mechanisms regulating progress toward beta cell… (More)
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Highly Cited
2002
Highly Cited
2002
Complete lack of transcription factor PDX-1 leads to pancreatic agenesis, whereas heterozygosity for PDX-1 mutations has been… (More)
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1994
1994
AICA riboside (0.1 to 1.0mM) caused a concentration-related increase of insulin output caused by D-glucose (5.6 to 20.0mM) in… (More)
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1993
1993
In the Goto-Kakizaki rat, a new genetic model of NIDDM, insulin response to glucose is selectively impaired. To elucidate the… (More)
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1992
1992
Northern-blot analysis was used to demonstrate that an increase in extracellular glucose concentration increased the content of… (More)
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Highly Cited
1990
Highly Cited
1990
It is generally believed that the initiation of insulin secretion by nutrient stimuli necessitates the generation of metabolic… (More)
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1987
1987
The effects of physiologic hyperinsulinemia and hyperaminoacidemia, alone or in combination, on leucine kinetics in vivo were… (More)
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1984
1984
The effects of leucine, its metabolites, and the 2-oxo acids of valine and isoleucine on protein synthesis and degradation in… (More)
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