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2-isopropylmalate synthase activity
Known as:
alpha-isopropylmalic synthetase activity
, 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity
, alpha-isopropylmalate synthetase activity
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Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+). [EC:2.3.3.13, RHEA:21527]
National Institutes of Health
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1984
1984
Cloning and characterization of yeast Leu4, one of two genes responsible for alpha-isopropylmalate synthesis.
L. Chang
,
T. Cunningham
,
P. R. Gatzek
,
W. J. Chen
,
G. Kohlhaw
Genetics
1984
Corpus ID: 36930268
By complementation of an alpha-isopropylmalate synthase-negative mutant of Saccharomyces cerevisiae (leu4 leu5), a plasmid was…
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