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2-hydroxyquinoline 5,6-dioxygenase activity

Known as: 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase activity, quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating), quinolin-2(1H)-one 5,6-dioxygenase activity 
Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+. [EC:]
National Institutes of Health

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The synthesis of 5-(dipropylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij] quinolin-2(1H)-one (5), a potent dopamine D2 agonist showing… Expand