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2-hydroxydesipramine
Known as:
2-OH-DMI
, 2-hydroxy-desipramine
, 2-hydroxydesmethylimipramine
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Desipramine
Tricyclic Antidepressive Agents
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Characterization of desmethylimipramine 2-hydroxylation in human foetal and adult liver microsomes.
E. Spina
,
G. Pacifici
,
C. von Bahr
,
A. Rane
Acta Pharmacologica et Toxicologica
2009
Corpus ID: 27155456
The rate of formation of 2-hydroxydesmethylimipramine was studied in microsomes from four human foetal and adult livers. The…
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1992
1992
Fluoxetine inhibits desipramine metabolism.
T. Wilens
,
J. Biederman
,
R. Baldessarini
,
S. P. McDermott
,
P. Puopolo
,
J. Flood
Archives of General Psychiatry
1992
Corpus ID: 20764996
To the Editor.— We read with interest the article by Nelson et al 1 on the treatment of depression with fluoxetine and…
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1987
1987
Urinary Desipramine Hydroxylation Index and Steady‐State Plasma Concentrations of Imipramine and Desipramine
E. Spina
,
A. Arena
,
F. Pisani
Therapeutic Drug Monitoring
1987
Corpus ID: 5056843
An index of desipramine (DMI) hydroxylation, calculated as the ratio between the amounts of DMI and 2-hydroxydesipramine (2-OH…
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1983
1983
Metabolism of imipramine in vitro: synthesis and characterization of N-hydroxydesmethylimipramine.
A. Beckett
,
A. Hutt
,
G. Navas
Xenobiotica; the fate of foreign compounds in…
1983
Corpus ID: 37470124
The synthesis of N-hydroxydesmethylimipramine via the corresponding primary hydroxylamine and oxime is described. The N…
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1983
1983
Distribution of Imipramine, Desipramine and Their Principal Metabolites Between Plasma, Red Blood Cells and Brain in Humans and Animal Models
Bogema
,
S. Chapman
1983
Corpus ID: 79087829
DISTRIBUTION OF IMIPRAMINE, DESIPRAMINE AND THEIR PRINCIPAL METABOLITES BETWEEN PLASMA, RED BLOOD CELLS AND BRAIN IN HUMANS AND…
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1981
1981
Quantitative mapping of metabolites of imipramine and desipramine in plasma samples by gas chromatographic-mass spectrometry.
N. Narasimhachari
,
J. Saady
,
R. O. Friedel
Biological Psychiatry
1981
Corpus ID: 12883578
Imipramine and desipramine are known to metabolize primarily by demethylation and hydroxylation. Hydroxy metabolites, 2…
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Review
1981
Review
1981
Theoretical studies on tricyclic antidepressants: III. Analysis of stereospecificity.
K. Sundaram
,
S. Mahajan
Physiological chemistry and physics
1981
Corpus ID: 39603012
By dynamic simulation of molecular structures in a digital computer, search was made for all possible ways of superposing a…
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1977
1977
Subacute imipramine: changes in single dose pharmacokinetics in rats.
A. Beaubien
,
L. Mathieu
,
J. A. Huddleston
,
H. James
Archives internationales de pharmacodynamie et de…
1977
Corpus ID: 25522397
Imipramine (10 mg/kg, p.o.) administered to male Wistar rats (133-178 g) twice daily for 3 weeks more than halved the control…
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1976
1976
Metabolism of an Antidepressant, Lofepramine (DB-2182) in Human
M. Kimura
,
K. Matsubayashi
,
H. Hakusui
,
M. Sano
,
T. Akimoto
1976
Corpus ID: 75444580
The concentrations of Lofepramine (DB-2182) and its metabolites in human blood and urine were studied by using gas…
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1971
1971
Hydroxylation and subsequent glucuronide conjugation of desmethylimipramine in rat liver microsomes.
C. von Bahr
,
L. Bertilsson
Xenobiotica; the fate of foreign compounds in…
1971
Corpus ID: 45550120
1. We have studied the hydroxylation and subsequent glucuronide conjugation of desmethylimipramine (DMI) as a two-step reaction…
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