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2-hydroxydesipramine

Known as: 2-OH-DMI, 2-hydroxy-desipramine, 2-hydroxydesmethylimipramine 
 
National Institutes of Health

Papers overview

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Highly Cited
1997
Highly Cited
1997
Cytochrome P450 (CYP) involved in the two major pathways of imipramine (IMI) was reappraised using human liver microsomes… Expand
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1997
1997
The antidepressant desipramine (DMI) and its principal metabolite 2-hydroxydesipramine (HDMI) have been radiolabeled with 11C for… Expand
1993
1993
OBJECTIVE To assess the developmental effects of desipramine (DMI) treatment on the electrocardiogram (ECG), we investigated… Expand
Highly Cited
1988
Highly Cited
1988
Urinary excretion of desipramine (DMI) and 2‐hydroxydesipramine (2‐OH‐DMI) after single oral doses of 25 mg DMI was investigated… Expand
Highly Cited
1987
Highly Cited
1987
The 2‐hydroxylation of desmethylimipramine (DMI) was studied in 14 healthy subjects previously phenotyped with respect to… Expand
1985
1985
Studies of the relationship between plasma concentrations of desipramine hydrochloride and clinical response have shown… Expand
Highly Cited
1984
Highly Cited
1984
The 2‐hydroxylation of desmethylimipramine (DMI) and the 4‐hydroxylation of debrisoquine (D) were studied in healthy subjects and… Expand
1984
1984
Plasma levels of desipramine (DMI) and the unconjugated form of its principal metabolite 2‐hydroxydesipramine (OH‐D) were… Expand
Highly Cited
1979
Highly Cited
1979
Abstract The tricyclic antidepressant imipramine and its metabolites desipramine, 2-hydroxyimipramine and 2-hydroxydesipramine… Expand
1971
1971
1. Imipramine and its oxidized metabolites 2-hydroxyimipramine, desmethylimipramine (DMI), 2-hydroxydesmethylimipramine (2-OH-DMI… Expand