2-hydroxyatorvastatin

HighlightsCardiovascular disease is a leading cause of morbidity and mortality.There is notable interindividual variation in… Expand

The pharmacokinetics of statins show substantial inter-subject variability. Increasing systemic exposure of statins may lead to… Expand

The present study aimed to evaluate the impact of CYP3A4*1G allele on the pharmacokinetics of atorvastatin in the Chinese Han… Expand

Coadministration of statins and fibrates is beneficial in some patients by allowing simultaneous reduction of triglycerides and… Expand

OBJECTIVE This study aimed to evaluate the effect of genetic polymorphisms of SLCO1B1 and ABCB1 on the pharmacokinetics of… Expand

The aim of the present study was to develop a chromatographic method for the analysis of atorvastatin, Ortho- and Para… Expand

BACKGROUND Prescription omega-3-acid ethyl esters (P-OM3) have been used as adjunctive therapy to statin drugs in patients with… Expand

Thirty‐two healthy volunteers with different SLCO1B1 genotypes ingested a 20 mg dose of atorvastatin and 10 mg dose of… Expand

Cholesterol-reducing statin drugs are the most frequently prescribed agents for reducing morbidity and mortality related to… Expand

A method for simultaneous quantitation of both the acid and lactone forms of atorvastatin, a new synthetic inhibitor of HMG-CoA… Expand