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2-hydroxyatorvastatin

Known as: 2-hydroxy-atorvastatin, ortho-hydroxyatorvastatin 
National Institutes of Health

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2 relations

Broader (1)

Atorvastatin calcium
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Development, validation and application of a novel HPLC-MS/MS method for the quantification of atorvastatin, bisoprolol and clopidogrel in a large cardiovascular patient cohort
2017
2017
High-Dose Metformin May Increase the Concentration of Atorvastatin in the Liver by Inhibition of Multidrug Resistance-Associated Protein 2.
2017
2017
The effect of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and 2-hydroxyatorvastatin in healthy Chinese people.
The pharmacokinetics of statins show substantial inter-subject variability. Increasing systemic exposure of statins may lead to… 
2014
2014
The effect of CYP3A4*1G allele on the pharmacokinetics of atorvastatin in Chinese han patients with coronary heart disease
The present study aimed to evaluate the impact of CYP3A4*1G allele on the pharmacokinetics of atorvastatin in the Chinese Han… 
Highly Cited
2011
Highly Cited
2011
Effect of Gemfibrozil and Fenofibrate on the Pharmacokinetics of Atorvastatin
Coadministration of statins and fibrates is beneficial in some patients by allowing simultaneous reduction of triglycerides and… 
2010
2010
Effects of SLCO1B1 and ABCB1 genotypes on the pharmacokinetics of atorvastatin and 2-hydroxyatorvastatin in healthy Korean subjects.
OBJECTIVE This study aimed to evaluate the effect of genetic polymorphisms of SLCO1B1 and ABCB1 on the pharmacokinetics of… 
2008
2008
Effect of omega-3-acid ethyl esters on steady-state plasma pharmacokinetics of atorvastatin in healthy adults.
BACKGROUND Prescription omega-3-acid ethyl esters (P-OM3) have been used as adjunctive therapy to statin drugs in patients with… 
Highly Cited
2007
Highly Cited
2007
Different Effects of SLCO1B1 Polymorphism on the Pharmacokinetics of Atorvastatin and Rosuvastatin
Thirty‐two healthy volunteers with different SLCO1B1 genotypes ingested a 20 mg dose of atorvastatin and 10 mg dose of… 
Highly Cited
2006
Highly Cited
2006
Validated HPLC–MS–MS method for simultaneous determination of atorvastatin and 2-hydroxyatorvastatin in human plasma—pharmacokinetic study
Cholesterol-reducing statin drugs are the most frequently prescribed agents for reducing morbidity and mortality related to… 
Highly Cited
1999
Highly Cited
1999
Quantitation of the acid and lactone forms of atorvastatin and its biotransformation products in human serum by high-performance liquid chromatography with electrospray tandem mass spectrometry.
A method for simultaneous quantitation of both the acid and lactone forms of atorvastatin, a new synthetic inhibitor of HMG-CoA… 
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