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Alzheimer's disease (AD) is the leading cause of senile dementia in today's society. Its debilitating symptoms are manifested by… Expand SummaryIntracellular recordings were performed in α1-pontine slice preparation of the rat brain containing the locus coeruleus… Expand The search for potent and selective A(2A) adenosine receptor agonists has been particularly fruitful in the early nineties. A… Expand Although molecular biology studies indicate the presence of adenosine A(2A) receptors in the rat hippocampus, the pharmacological… Expand The hippocampal GABAergic system is assumed not to be a target for purine modulation. We have now confirmed that neither… Expand 1 In the present study, we investigated the ability of a recently introduced non‐xanthine A2A receptor antagonist, ZM241385 (4‐(2… Expand Expression of the early-gene c-fos is an useful method for studying potential sites of action of drugs active in the CNS… Expand A series of new 2-aralkynyl and 2-heteroaralkynyl derivatives of NECA were synthesized and studied in binding and functional… Expand The effects of N6-L-(phenylisopropyl)adenosine, cyclohexyladenosine and adenosine-5'-N-ethylcarboxamide on sleep were examined in… Expand Various adenosine derivatives, methylxanthines and other compounds were tested for their abilities to inhibit the rapid uptake of… Expand