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2-ethoxyestradiol
Known as:
1,3,5(5)-estratrien-2,3,17-triol 2-ethyl ether
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Estradiol
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
2-Ethoxyestradiol is antimitogenic and attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling.
S. Tofovic
,
Xinchen Zhang
,
Hong Zhu
,
E. Jackson
,
O. Rafikova
,
G. Petrusevska
Vascular pharmacology
2008
Corpus ID: 23811636
2007
2007
2-Methoxyestradiol and 2-Ethoxyestradiol Retard the Progression of Renal Disease in Aged, Obese, Diabetic ZSF1 Rats
Xinchen Zhang
,
Youhong Jia
,
E. Jackson
,
S. Tofovic
Journal of Cardiovascular Pharmacology
2007
Corpus ID: 24069475
The metabolic syndrome is a main cause for cardiovascular disease and for the accelerating epidemic of chronic renal failure…
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Highly Cited
2000
Highly Cited
2000
A steroid derivative with paclitaxel-like effects on tubulin polymerization.
P. Verdier-Pinard
,
Z. Wang
,
A. Mohanakrishnan
,
M. Cushman
,
E. Hamel
Molecular Pharmacology
2000
Corpus ID: 12139366
The endogenous estrogen metabolite 2-methoxyestradiol has modest antimitotic activity that may result from a weak interaction at…
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Highly Cited
2000
Highly Cited
2000
Synthesis of B-ring homologated estradiol analogues that modulate tubulin polymerization and microtubule stability.
Z. Wang
,
D. Yang
,
+4 authors
M. Cushman
Journal of Medicinal Chemistry
2000
Corpus ID: 22486944
2-Methoxyestradiol is a cytotoxic human metabolite of estradiol with the ability to bind to the colchicine site of tubulin and…
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Highly Cited
1995
Highly Cited
1995
Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to…
M. Cushman
,
H. He
,
J. Katzenellenbogen
,
C. Lin
,
E. Hamel
Journal of Medicinal Chemistry
1995
Corpus ID: 25869787
In order to define the structural parameters associated with the antitubulin activity and cytotoxicity of 2-methoxyestradiol, a…
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