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2-dehydro-3-deoxyphosphoheptonate aldolase activity

Known as: phospho-2-oxo-3-deoxyheptonate aldolase activity, D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity, 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity 
Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. [EC:2… 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
OpenMebius: An Open Source Software for Isotopically Nonstationary 13C-Based Metabolic Flux Analysis
The in vivo measurement of metabolic flux by 13C-based metabolic flux analysis (13C-MFA) provides valuable information regarding… 
2014
2014
Intracellular Hydrogen Peroxide and Superoxide Poison 3-Deoxy-d-Arabinoheptulosonate 7-Phosphate Synthase, the First Committed Enzyme in the Aromatic Biosynthetic Pathway of Escherichia coli
ABSTRACT In Escherichia coli, aromatic compound biosynthesis is the process that has shown the greatest sensitivity to hydrogen… 
Highly Cited
2013
Highly Cited
2013
Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed‐batch CHO cell culture
Cell metabolism can vary considerably over the course of a typical fed‐batch antibody production process. However, the… 
2011
2011
Systematic synthesis of inhibitors of the two first enzymes of the bacterial heptose biosynthetic pathway: towards antivirulence molecules targeting lipopolysaccharide biosynthesis.
L-Heptoses (L-glycero-D-manno-heptopyranoses) are constituents of the inner core of lipolysaccharide (LPS), a molecule playing… 
Highly Cited
2010
Highly Cited
2010
Synergistic Allostery, a Sophisticated Regulatory Network for the Control of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis*
The shikimate pathway, responsible for aromatic amino acid biosynthesis, is required for the growth of Mycobacterium tuberculosis… 
Highly Cited
2004
Highly Cited
2004
Crystal structure of the reaction complex of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Thermotoga maritima refines the catalytic mechanism and indicates a new mechanism of allosteric…
Highly Cited
1994
Highly Cited
1994
Engineering of Escherichia coli central metabolism for aromatic metabolite production with near theoretical yield
Escherichia coli and many other microorganisms synthesize aromatic amino acids through the condensation reaction between… 
Highly Cited
1985
Highly Cited
1985
The 3-dehydroquinate synthase activity of the pentafunctional arom enzyme complex of Neurospora crassa is Zn2+-dependent.
We have demonstrated the co-purification in constant ratio of all five activities of the pentafunctional arom enzyme complex from… 
1978
1978
Separation of younger red cells with improved survival in vivo: an approach to chronic transfusion therapy.
Transfusion of donor blood containing predominantly younger red cells with prolonged survival in vivo could significantly reduce… 
Highly Cited
1977
Highly Cited
1977
Dual enzymatic routes to L-tyrosine and L-phenylalanine via pretyrosine in Pseudomonas aeruginosa.
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