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2-dehydro-3-deoxyphosphoheptonate aldolase activity
Known as:
phospho-2-oxo-3-deoxyheptonate aldolase activity
, D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity
, 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity
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Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. [EC:2…
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National Institutes of Health
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Highly Cited
2014
Highly Cited
2014
OpenMebius: An Open Source Software for Isotopically Nonstationary 13C-Based Metabolic Flux Analysis
Shuichi Kajihata
,
C. Furusawa
,
F. Matsuda
,
H. Shimizu
BioMed research international
2014
Corpus ID: 11357097
The in vivo measurement of metabolic flux by 13C-based metabolic flux analysis (13C-MFA) provides valuable information regarding…
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2014
2014
Intracellular Hydrogen Peroxide and Superoxide Poison 3-Deoxy-d-Arabinoheptulosonate 7-Phosphate Synthase, the First Committed Enzyme in the Aromatic Biosynthetic Pathway of Escherichia coli
J. M. Sobota
,
M. Gu
,
J. Imlay
Journal of bacteriology
2014
Corpus ID: 22507098
ABSTRACT In Escherichia coli, aromatic compound biosynthesis is the process that has shown the greatest sensitivity to hydrogen…
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Highly Cited
2013
Highly Cited
2013
Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed‐batch CHO cell culture
Neil Templeton
,
Jason Dean
,
Pranhitha Reddy
,
Jamey D. Young
Biotechnology and bioengineering
2013
Corpus ID: 6287339
Cell metabolism can vary considerably over the course of a typical fed‐batch antibody production process. However, the…
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2011
2011
Systematic synthesis of inhibitors of the two first enzymes of the bacterial heptose biosynthetic pathway: towards antivirulence molecules targeting lipopolysaccharide biosynthesis.
M. Durka
,
A. Tikad
,
+8 authors
S. Vincent
Chemistry
2011
Corpus ID: 22737070
L-Heptoses (L-glycero-D-manno-heptopyranoses) are constituents of the inner core of lipolysaccharide (LPS), a molecule playing…
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Highly Cited
2010
Highly Cited
2010
Synergistic Allostery, a Sophisticated Regulatory Network for the Control of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis*
C. J. Webby
,
W. Jiao
,
+5 authors
E. Parker
The Journal of Biological Chemistry
2010
Corpus ID: 205299991
The shikimate pathway, responsible for aromatic amino acid biosynthesis, is required for the growth of Mycobacterium tuberculosis…
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Highly Cited
2004
Highly Cited
2004
Crystal structure of the reaction complex of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Thermotoga maritima refines the catalytic mechanism and indicates a new mechanism of allosteric…
I. Shumilin
,
R. Bauerle
,
Jing Wu
,
R. Woodard
,
R. Kretsinger
Journal of molecular biology
2004
Corpus ID: 29529048
Highly Cited
1994
Highly Cited
1994
Engineering of Escherichia coli central metabolism for aromatic metabolite production with near theoretical yield
R. Patnaik
,
J. Liao
Applied and environmental microbiology
1994
Corpus ID: 29494973
Escherichia coli and many other microorganisms synthesize aromatic amino acids through the condensation reaction between…
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Highly Cited
1985
Highly Cited
1985
The 3-dehydroquinate synthase activity of the pentafunctional arom enzyme complex of Neurospora crassa is Zn2+-dependent.
J. Lambert
,
M. Boocock
,
J. Coggins
The Biochemical journal
1985
Corpus ID: 31999641
We have demonstrated the co-purification in constant ratio of all five activities of the pentafunctional arom enzyme complex from…
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1978
1978
Separation of younger red cells with improved survival in vivo: an approach to chronic transfusion therapy.
S. Piomelli
,
C. Seaman
,
+4 authors
L. Corash
Proceedings of the National Academy of Sciences…
1978
Corpus ID: 21402739
Transfusion of donor blood containing predominantly younger red cells with prolonged survival in vivo could significantly reduce…
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Highly Cited
1977
Highly Cited
1977
Dual enzymatic routes to L-tyrosine and L-phenylalanine via pretyrosine in Pseudomonas aeruginosa.
N. Patel
,
D. Pierson
,
R. Jensen
The Journal of biological chemistry
1977
Corpus ID: 16370293
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