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2-dehydro-3-deoxyphosphoheptonate aldolase activity

Known as: phospho-2-oxo-3-deoxyheptonate aldolase activity, D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity, 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity 
Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. [EC:2… Expand
National Institutes of Health

Papers overview

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2014
2014
Intracellular hydrogen peroxide and superoxide poison 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase, the first committed enzyme in the aromatic biosynthetic pathway of Escherichia coli.
In Escherichia coli, aromatic compound biosynthesis is the process that has shown the greatest sensitivity to hydrogen peroxide… Expand
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Highly Cited
2014
Highly Cited
2014
OpenMebius: An Open Source Software for Isotopically Nonstationary 13C-Based Metabolic Flux Analysis
The in vivo measurement of metabolic flux by 13C-based metabolic flux analysis (13C-MFA) provides valuable information regarding… Expand
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Highly Cited
2013
Highly Cited
2013
Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed‐batch CHO cell culture
Cell metabolism can vary considerably over the course of a typical fed‐batch antibody production process. However, the… Expand
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Highly Cited
2010
Highly Cited
2010
Synergistic Allostery, a Sophisticated Regulatory Network for the Control of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis*
The shikimate pathway, responsible for aromatic amino acid biosynthesis, is required for the growth of Mycobacterium tuberculosis… Expand
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Highly Cited
2005
Highly Cited
2005
Substrate ambiguity and crystal structure of Pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase: an ancestral 3-deoxyald-2-ulosonate-phosphate synthase?
3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAH7PS) catalyzes the condensation reaction between phosphoenolpyruvate… Expand
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2005
2005
Synthesis, surface active and antimicrobial properties of new alkyl 2,6-dideoxy-L-arabino-hexopyranosides.
Synthesis of alkyl 2,6-dideoxy-L-arabino-hexopyranosides was accomplished by the reaction of 1,5-anhydro-2,6-dideoxy-L-arabino… Expand
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Highly Cited
2004
Highly Cited
2004
Crystal structure of the reaction complex of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Thermotoga maritima refines the catalytic mechanism and indicates a new mechanism of allosteric…
3-Deoxy-d-arabino-heptulosonate-7-phosphate synthase (DAHPS) catalyzes the first reaction of the aromatic biosynthetic pathway in… Expand
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Highly Cited
1994
Highly Cited
1994
Engineering of Escherichia coli central metabolism for aromatic metabolite production with near theoretical yield.
Escherichia coli and many other microorganisms synthesize aromatic amino acids through the condensation reaction between… Expand
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Highly Cited
1986
Highly Cited
1986
Comparative action of glyphosate as a trigger of energy drain in eubacteria.
Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa, each possessing a 5-enolpyruvylshikimate 3-phosphate synthase… Expand
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Highly Cited
1977
Highly Cited
1977
Dual enzymatic routes to L-tyrosine and L-phenylalanine via pretyrosine in Pseudomonas aeruginosa.
Pretyrosine, an intermediate of L-tyrosine biosynthesis in blue-green algae, was found to be enzymatically formed and utilized in… Expand
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