2-dehydro-3-deoxyphosphoheptonate aldolase activity

Known as: phospho-2-oxo-3-deoxyheptonate aldolase activity, D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity, 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity 
Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. [EC:2… (More)
National Institutes of Health

Papers overview

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2014
2014
OpenMebius: An Open Source Software for Isotopically Nonstationary 13C-Based Metabolic Flux Analysis
The in vivo measurement of metabolic flux by (13)C-based metabolic flux analysis ((13)C-MFA) provides valuable information… (More)
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Highly Cited
2013
Highly Cited
2013
Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture.
Cell metabolism can vary considerably over the course of a typical fed-batch antibody production process. However, the… (More)
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2011
2011
Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design.
Tuberculosis remains a serious global health threat, with the emergence of multidrug-resistant strains highlighting the urgent… (More)
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2010
2010
Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis.
The shikimate pathway, responsible for aromatic amino acid biosynthesis, is required for the growth of Mycobacterium tuberculosis… (More)
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2005
2005
Substrate ambiguity and crystal structure of Pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase: an ancestral 3-deoxyald-2-ulosonate-phosphate synthase?
3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAH7PS) catalyzes the condensation reaction between phosphoenolpyruvate… (More)
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2004
2004
Crystal structure of the reaction complex of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Thermotoga maritima refines the catalytic mechanism and indicates a new mechanism of allosteric…
3-Deoxy-d-arabino-heptulosonate-7-phosphate synthase (DAHPS) catalyzes the first reaction of the aromatic biosynthetic pathway in… (More)
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Highly Cited
1994
Highly Cited
1994
Engineering of Escherichia coli central metabolism for aromatic metabolite production with near theoretical yield.
Escherichia coli and many other microorganisms synthesize aromatic amino acids through the condensation reaction between… (More)
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1978
1978
Separation of younger red cells with improved survival in vivo: an approach to chronic transfusion therapy.
Transfusion of donor blood containing predominantly younger red cells with prolonged survival in vivo could significantly reduce… (More)
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1977
1977
Dual enzymatic routes to L-tyrosine and L-phenylalanine via pretyrosine in Pseudomonas aeruginosa.
Pretyrosine, an intermediate of L-tyrosine biosynthesis in blue-green algae, was found to be enzymatically formed and utilized in… (More)
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1974
1974
Regulation of aromatic amino acid biosynthesis in Bacillus subtilis 168. Purification, characterization, and subunit structure of the bifunctional enzyme 3-deoxy-D-arabinoheptulosonate 7-phosphate…
A bifunctional enzyme, consisting of 3-deoxy-n-arabinoheptulosonate 7-phosphate synthetase and chorismate mutase, has been… (More)
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