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2-Acetylaminofluorene
Known as:
N-Acetyl-2-Aminofluorene
, 2-Acetamidofluorene
, Fluoren 2 ylacetamide
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A synthetic, light tan crystalline solid that is insoluble in water and soluble in alcohols, glycols, ether, acetic acid, and fat solvents. It is…
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National Institutes of Health
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Related topics
Related topics
20 relations
Narrower (10)
2,7-diacetylaminofluorene
2-(bromoacetylamino)fluorene
2-acetylaminofluoren-9-one
2-acetylaminofluorene-N-sulfate
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2-Acetylaminofluorene:MCnc:Pt:Air:Qn
In Blood
agonists
analogs & derivatives
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Broader (2)
Acetylaminofluorene
Carcinogens
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-κB signaling
M. Kuo
,
Zesheng Liu
,
+4 authors
H. Unate
Oncogene
2002
Corpus ID: 25710465
The expression of P-glycoprotein encoded by the multidrug resistance (MDR1) gene is associated with the emergence of the MDR…
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Highly Cited
1999
Highly Cited
1999
Bone marrow as a potential source of hepatic oval cells.
B. Petersen
,
W. Bowen
,
+6 authors
J. Goff
Science
1999
Corpus ID: 19886965
Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production…
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Highly Cited
1996
Highly Cited
1996
Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.
T. Shimada
,
C. L. Hayes
,
+4 authors
T. Sutter
Cancer Research
1996
Corpus ID: 13508470
A human cytochrome P-450 (P450) 1B1 cDNA was expressed in Saccharomyces cerevisiae and the microsomes containing P450 1B1 were…
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Review
1994
Review
1994
Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms.
Y. Zhang
,
P. Talalay
Cancer Research
1994
Corpus ID: 10121968
Organic isothiocyanates block the production of tumors induced in rodents by diverse carcinogens (polycyclic aromatic…
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Review
1990
Review
1990
Cell proliferation in carcinogenesis.
S. Cohen
,
L. Ellwein
Science
1990
Corpus ID: 5710369
Chemicals that induce cancer at high doses in animal bioassays often fail to fit the traditional characterization of genotoxins…
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Highly Cited
1984
Highly Cited
1984
Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo.
R. Gupta
Proceedings of the National Academy of Sciences…
1984
Corpus ID: 22483575
We have examined the distribution of individual adducts in repetitive DNA sequences of rat liver in vivo after a single dose of…
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Review
1983
Review
1983
The role of glutathione in detoxication
B. Ketterer
,
B. Coles
,
D. Meyer
Environmental Health Perspectives
1983
Corpus ID: 3080171
Glutathione (GSH) is a strong nucleophile which reacts well with soft electrophiles, but poorly with both weak and strong…
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Highly Cited
1972
Highly Cited
1972
Carcinogens as frameshift mutagens: metabolites and derivatives of 2-acetylaminofluorene and other aromatic amine carcinogens.
B. Ames
,
E. Gurney
,
J. Miller
,
H. Bartsch
Proceedings of the National Academy of Sciences…
1972
Corpus ID: 34497989
Several carcinogenic metabolites of the carcinogen 2-acetyl-aminofluorene, especially 2-nitrosofluorene and N-hydroxy-2…
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Highly Cited
1971
Highly Cited
1971
Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.
C. Peraino
,
R. Fry
,
E. Staffeldt
Cancer Research
1971
Corpus ID: 17339055
Summary The effects of dietary phenobarbital on hepatocarcinogenesis in rats fed 2-acetylaminofluorene (AAF) were studied. The…
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Highly Cited
1961
Highly Cited
1961
N-Hydroxy-2-acetylaminofluorene: a metabolite of 2-acetylaminofluorene with increased carcinogenic activity in the rat.
E. Miller
,
J. Miller
,
H. A. Hartmann
Cancer Research
1961
Corpus ID: 18960135
Summary N-Hydroxy-2-acetylaminofluorene, a major metabolite of 2-acetylaminofluorene in the rat, was more active than the parent…
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