FAQ

2-Acetylaminofluorene

Known as: N-Acetyl-2-Aminofluorene, 2-Acetamidofluorene, Fluoren 2 ylacetamide 
A synthetic, light tan crystalline solid that is insoluble in water and soluble in alcohols, glycols, ether, acetic acid, and fat solvents. It is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1944-2017
05019442016

Related topics

Related topics

19 relations

Narrower (9)

2,7-diacetylaminofluorene2-(bromoacetylamino)fluorene2-acetylaminofluoren-9-one2-acetylaminofluorene-N-sulfate
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Broader (2)

AcetylaminofluoreneCarcinogens
In Bloodadministration & dosageagonistsantagonists & inhibitors
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Related mentions per year

Related mentions per year

1939-2018
19401960198020002020
2-Acetylaminofluorene
agonists
Carcinogens
chemical synthesis
Acetylaminofluorene
standards characteristics

Papers overview

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Highly Cited
1999
Highly Cited
1999
Bone marrow as a potential source of hepatic oval cells.
Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production… (More)
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Highly Cited
1996
Highly Cited
1996
Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.
A human cytochrome P-450 (P450) 1B1 cDNA was expressed in Saccharomyces cerevisiae and the microsomes containing P450 1B1 were… (More)
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Highly Cited
1990
Highly Cited
1990
Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450.
The human P-450 CYP1A1 gene and a P450IA2 complementary DNA have been expressed in Cos-1 cells and the expressed proteins were… (More)
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Highly Cited
1978
Highly Cited
1978
Quantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital.
nodules (14, 29). These in turn may derive from smaller microscopic foci of modified hepatocytes referred to as islands (10, 30… (More)
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Highly Cited
1975
Highly Cited
1975
Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.
Earlier studies showed that phenobarbital feeding enhanced hepatic tumorigenesis in rats previously fed 2-acetylaminofluorene for… (More)
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Highly Cited
1971
Highly Cited
1971
Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.
The effects of dietary phénobarbital on hepatocarcinogenesis in rats fed 2-acetylaminofluorene (AAF) were studied. The… (More)
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Highly Cited
1971
Highly Cited
1971
Regression and persistence of hyperplastic hepatic nodules induced by N-2-Fluorenylacetamide and their relationship to hepatocarcinogenesis.
A dietary regimen containing the carcinogen N-2@fluorenyl acetamide for the induction of hyperplastic hepatic nodules and… (More)
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1964
1964
Enzymatic N-hydroxylation of the Carcinogen 2-acetylaminofluorene and the Metabolism of N-hydroxy-2-acetylaminofluorene-9-14c in Vitro.
In 1960, Cramer, Miller, and Miller (1) reported the discovery of a new metabolite of the carcinogen 2-acetylaminofluorene, and… (More)
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Highly Cited
1961
Highly Cited
1961
N-Hydroxy-2-acetylaminofluorene: a metabolite of 2-acetylaminofluorene with increased carcinogenic activity in the rat.
N-Hydroxy-~-acetylaminofluorene, a major metabolite of ~-acetylaminofluorene in the rat, was more active than the parent amide in… (More)
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1960
1960
N-Hydroxylation: A new metabolic reaction observed in the rat with the carcinogen 2-acetylaminofluorene.
In their comprehensive work on 2acetylaminofluorenel (Fig. 1) the Weisburgers and Morris (l-4) have identified six phenolic… (More)
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