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2-Acetylaminofluorene

Known as: N-Acetyl-2-Aminofluorene, 2-Acetamidofluorene, Fluoren 2 ylacetamide 
A synthetic, light tan crystalline solid that is insoluble in water and soluble in alcohols, glycols, ether, acetic acid, and fat solvents. It is… 
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (10)

2,7-diacetylaminofluorene2-(bromoacetylamino)fluorene2-acetylaminofluoren-9-one2-acetylaminofluorene-N-sulfate
2-Acetylaminofluorene:MCnc:Pt:Air:QnIn Bloodagonistsanalogs & derivatives

Broader (2)

AcetylaminofluoreneCarcinogens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-κB signaling
The expression of P-glycoprotein encoded by the multidrug resistance (MDR1) gene is associated with the emergence of the MDR… 
Highly Cited
1999
Highly Cited
1999
Bone marrow as a potential source of hepatic oval cells.
Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production… 
Highly Cited
1996
Highly Cited
1996
Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.
A human cytochrome P-450 (P450) 1B1 cDNA was expressed in Saccharomyces cerevisiae and the microsomes containing P450 1B1 were… 
Review
1994
Review
1994
Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms.
Organic isothiocyanates block the production of tumors induced in rodents by diverse carcinogens (polycyclic aromatic… 
Review
1990
Review
1990
Cell proliferation in carcinogenesis.
Chemicals that induce cancer at high doses in animal bioassays often fail to fit the traditional characterization of genotoxins… 
Highly Cited
1984
Highly Cited
1984
Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo.
  • R. Gupta
  • Proceedings of the National Academy of Sciences…
  • 1984
  • Corpus ID: 22483575
We have examined the distribution of individual adducts in repetitive DNA sequences of rat liver in vivo after a single dose of… 
Review
1983
Review
1983
The role of glutathione in detoxication
Glutathione (GSH) is a strong nucleophile which reacts well with soft electrophiles, but poorly with both weak and strong… 
Highly Cited
1972
Highly Cited
1972
Carcinogens as frameshift mutagens: metabolites and derivatives of 2-acetylaminofluorene and other aromatic amine carcinogens.
Several carcinogenic metabolites of the carcinogen 2-acetyl-aminofluorene, especially 2-nitrosofluorene and N-hydroxy-2… 
Highly Cited
1971
Highly Cited
1971
Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.
Summary The effects of dietary phenobarbital on hepatocarcinogenesis in rats fed 2-acetylaminofluorene (AAF) were studied. The… 
Highly Cited
1961
Highly Cited
1961
N-Hydroxy-2-acetylaminofluorene: a metabolite of 2-acetylaminofluorene with increased carcinogenic activity in the rat.
Summary N-Hydroxy-2-acetylaminofluorene, a major metabolite of 2-acetylaminofluorene in the rat, was more active than the parent… 
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