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2,6-diaminopurine

Known as: 2-aminoadenine, DAP, 1H-Purine-2,6-diamine 
One of a number of organic compounds that share a similar purine structure and possess antiviral and antitumor properties. 2,6-Diaminopurine… 
National Institutes of Health

Related topics

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Broader (2)

2-AminopurineNucleic Acid Synthesis Inhibitors
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

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2006
2006
Three conserved guanosines approach the reaction site in native and minimal hammerhead ribozymes.
Native hammerhead ribozymes contain RNA domains that enable high catalytic activity under physiological conditions, where minimal… 
1985
1985
Acyclic analogues of 2'-deoxynucleosides related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine as potential antiviral agents.
A series of acyclic analogues of 2'-deoxynucleosides related in structure to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine (DHPG, 1… 
1976
1976
Poly(2-aminoadenylic acid): interaction with poly(uridylic acid).
Poly(2-aminoadenylic acid) forms both double and triple helices with poly(uridylic acid) [poly(U)]. The 2-amino group forms a… 
1975
1975
Synthesis and antifolate activity of new diaminopyrimidines and diaminopurines in enzymatic and cellular systems.
The following new 2,4-diamino-6-methylpyrimidines, 5-cyclohexylmethyl, 5-cyclohexylethyl,and 5-(2-naphthyl), as well as 2,6… 
Review
1973
Review
1973
Diaminopurine-resistant mutants of cultured, diploid human fibroblasts.
Clones of cells resistant to 2,6-diaminopurine were detected in skin fibroblast cultures derived from 13 of 21 normal humans of… 
1969
1969
Mutant of Yeast Sensitive to 2,6-Diaminopurine
A mutant of yeast sensitive to growth inhibition by 2,6-diaminopurine (2,6-DAP) was analyzed genetically and found to be a double… 
1958
1958
Metabolism of resistant mutants of Streptococcus faecalis. I. Isolation and characterization of the mutants.
Summary The selection and maintenance of seven antimetabolite-resistant strains of Streptococcus faecalis have been described… 
1953
1953
Resistance in Leukemic Cells to an Adenine Antagonist, 6-Mercaptopurine
  • L. Law
  • Proceedings of the Society for Experimental…
  • 1953
  • Corpus ID: 45276940
Summary 1. The adenine analog 6-mercaptopurine has been shown to inhibit leukemic-cell growth of the acute lymphocytic leukemia L… 
Highly Cited
1951
Highly Cited
1951
Observations on inhibition of nucleic acid synthesis resulting from administration of nitrogen mustard, urethan,. colchicine, 2,6-diaminopurine, 8-azaguanine, potassium arsenite, and cortisone.
Using the technic of measuring the incorporation of formate carbon into nucleic acid purines of control and treated mice, data… 
1951
1951
Sterilization of leukemic cells in vivo and in vitro.
1. An in vivo technic for inactivating leukemic cells has been described as an aid in differentiating between modes of action of…