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2,5-dihydroxymethyl-3,6-dimethylpyrazine

Known as: liguzinediol 
National Institutes of Health

Papers overview

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2016
2016
  • Xiang Wu, X. Qi, +7 authors H. Bian
  • Biomedicine & pharmacotherapy = Biomedecine…
  • 2016
  • Corpus ID: 3931619
Cardiac fibrosis plays a causal role in the development of heart failure, and anti-fibrotic therapy represents a promising… Expand
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2014
2014
Aim:Liguzinediol is a novel derivative of ligustrazine isolated from the traditional Chinese medicine Chuanxiong (Ligusticum… Expand
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2014
2014
The potent positive inotropic effect, together with the relatively low safety risk of liguzinediol (LZDO), relative to currently… Expand
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2014
2014
Ultra-flow liquid chromatography/quadrupole-time-of-flight mass spectrometry (UFLC/Q-TOF MS) method combined with metabolitepilot… Expand
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2013
2013
Liguzinediol (LZDO) ester prodrugs 3–5 were synthesized and evaluated in vitro and in vivo for their potential use in prolonging… Expand
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2013
2013
Objective: To establish a simple and sensitive LC-MS/MS method for determining liguzinediol and study the pharmacokinetics of… Expand
2012
2012
Ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/QTOF MS) was employed to investigate… Expand
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2012
2012
AIMS The present work investigated the underlying mechanism for the positive inotropic effect of liguzinediol (LZDO) in isolated… Expand
2011
2011
AIM To investigate the acute toxicity of liguzinediol.METHODS Lethal dose 50(LD_(50))of liguzinediol was determinated by… Expand
2009
2009
AIM To investigate the inotropic effect of liguzinediol in normal isolated rat hearts and to elucidate its mechanism.METHODS… Expand