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2,5-dihydroxymethyl-3,6-dimethylpyrazine

Known as: liguzinediol 
 
National Institutes of Health

Papers overview

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2016
2016
Cardiac fibrosis plays a causal role in the development of heart failure, and anti-fibrotic therapy represents a promising… Expand
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2014
2014
Aim:Liguzinediol is a novel derivative of ligustrazine isolated from the traditional Chinese medicine Chuanxiong (Ligusticum… Expand
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2013
2013
Liguzinediol (LZDO) ester prodrugs 3–5 were synthesized and evaluated in vitro and in vivo for their potential use in prolonging… Expand
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2013
2013
Objective: To establish a simple and sensitive LC-MS/MS method for determining liguzinediol and study the pharmacokinetics of… Expand
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2012
2012
Ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/QTOF MS) was employed to investigate… Expand
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2012
2012
AIMS The present work investigated the underlying mechanism for the positive inotropic effect of liguzinediol (LZDO) in isolated… Expand
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2012
2012
OBJECTIVE To explore the mechanism underlying positive inotropic effect in rat isolated hearts and evaluate cardiac safety of… Expand
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2011
2011
AIM To investigate the acute toxicity of liguzinediol.METHODS Lethal dose 50(LD_(50))of liguzinediol was determinated by… Expand
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2011
2011
Aim To establish a simple and accurate method for determination of Liguzinediol by ultra performance liquid chromatography(UPLC… Expand
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2009
2009
AIM To investigate the inotropic effect of liguzinediol in normal isolated rat hearts and to elucidate its mechanism.METHODS… Expand
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