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2,4-pyrrolidine dicarboxylate

Known as: pyrrolidine-2,4-dicarboxylate 
 
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
The extracellular concentration of glutamate is highly regulated by transporter proteins, due to its neurotoxic properties… Expand
2003
2003
An increased concentration of extracellular glutamate is associated with neuronal damage induced by cerebral ischemia. We have… Expand
2001
2001
Increased levels of extracellular excitatory amino acids and failure of energy metabolism are two conditions associated with… Expand
Highly Cited
2001
Highly Cited
2001
Several lines of evidence implicate excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis (ALS). Transgenic… Expand
Highly Cited
1999
Highly Cited
1999
Transporters are thought to assist in the termination of synaptic transmission at some synapses by removing neurotransmitter from… Expand
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1997
1997
This study examined the effects of chronic intrastriatal infusion of L-trans-pyrrolidine-2,4-dicarboxylate (PDC), a selective… Expand
Highly Cited
1996
Highly Cited
1996
Because of the well‐documented importance of glutamate uptake in protecting neurons against glutamate toxicity, we were… Expand
Highly Cited
1996
Highly Cited
1996
We studied the early and late effects of L‐trans‐pyrrolidine‐2,4‐dicarboxylate (PDC), a competitive inhibitor of glutamate uptake… Expand
Highly Cited
1996
Highly Cited
1996
It is known that neurons exposed to high concentrations of glutamate degenerate and die. The clearance of this amino acid from… Expand
Highly Cited
1991
Highly Cited
1991
In order to determine the conformational requirements for binding of L-glutamate to the proteins involved in the process of… Expand