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2,4-pyrrolidine dicarboxylate

Known as: pyrrolidine-2,4-dicarboxylate 
 
National Institutes of Health

Papers overview

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2005
2005
The extracellular concentration of glutamate is highly regulated by transporter proteins, due to its neurotoxic properties… Expand
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2003
2003
An increased concentration of extracellular glutamate is associated with neuronal damage induced by cerebral ischemia. We have… Expand
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Highly Cited
2001
Highly Cited
2001
Several lines of evidence implicate excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis (ALS). Transgenic… Expand
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2001
2001
Increased levels of extracellular excitatory amino acids and failure of energy metabolism are two conditions associated with… Expand
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Highly Cited
1999
Highly Cited
1999
Transporters are thought to assist in the termination of synaptic transmission at some synapses by removing neurotransmitter from… Expand
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1997
1997
This study examined the effects of chronic intrastriatal infusion of L-trans-pyrrolidine-2,4-dicarboxylate (PDC), a selective… Expand
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1996
1996
Because of the well-documented importance of glutamate uptake in protecting neurons against glutamate toxicity, we were… Expand
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1996
1996
We studied the early and late effects of L-trans-pyrrolidine-2,4-dicarboxylate (PDC), a competitive inhibitor of glutamate uptake… Expand
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1996
1996
It is known that neurons exposed to high concentrations of glutamate degenerate and die. The clearance of this amino acid from… Expand
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Highly Cited
1991
Highly Cited
1991
In order to determine the conformational requirements for binding of L-glutamate to the proteins involved in the process of… Expand
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