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2,3-oxidosqualene

Known as: squalene-2,3-epoxide, 2,3-EDSQ, 2,3-epoxy-2,3-dihydrosqualene 
 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (1)

Squalene
analogs & derivatives

Narrower (2)

squalene monohydroperoxidesqualene peroxide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Cloning and Functional Characterization of Three Branch Point Oxidosqualene Cyclases from Withania somnifera (L.) Dunal*
Background: Pharmacological investigations position withanolides as important bioactive molecules demanding their copious… Expand
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Highly Cited
2012
Highly Cited
2012
Divergent evolution of oxidosqualene cyclases in plants.
Triterpenes are one of the largest classes of plant metabolites and have important functions. A diverse array of triterpenoid… Expand
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Highly Cited
2008
Highly Cited
2008
Licorice β-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin
Glycyrrhizin, a major bioactive compound derived from the underground parts of Glycyrrhiza (licorice) plants, is a triterpene… Expand
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Highly Cited
2004
Highly Cited
2004
Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase
In higher organisms the formation of the steroid scaffold is catalysed exclusively by the membrane-bound oxidosqualene cyclase… Expand
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Highly Cited
2003
Highly Cited
2003
Enhanced Synthesis of the Oxysterol 24(S),25-Epoxycholesterol in Macrophages by Inhibitors of 2,3-Oxidosqualene:Lanosterol Cyclase: A Novel Mechanism for the Attenuation of Foam Cell Formation
Abstract— Oxysterols are key regulators of lipid metabolism and regulate gene expression by activating the liver X receptor (LXR… Expand
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Highly Cited
1997
Highly Cited
1997
Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin.
2,3-Oxidosqualene:lanosterol cyclase (OSC, E.C. 5.4.99.7) represents a unique target for a cholesterol lowering drug. Partial… Expand
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Highly Cited
1997
Highly Cited
1997
Structure and function of a squalene cyclase.
The crystal structure of squalene-hopene cyclase from Alicyclobacillus acidocaldarius was determined at 2.9 angstrom resolution… Expand
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Highly Cited
1996
Highly Cited
1996
Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells.
Within the cholesterol biosynthesis cascade, the enzyme 2,3-oxidosqualene cyclase [EC 5.4.99.7] is of special interest due to its… Expand
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Highly Cited
1977
Highly Cited
1977
Yeast mutants deficient in heme biosynthesis and a heme mutant additionally blocked in cyclization of 2,3-oxidosqualene.
Mutants of Saccharomyces cerevisiae were isolated which were blocked in heme biosynthesis and required heme for growth on a… Expand
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Highly Cited
1967
Highly Cited
1967
A soluble 2,3-oxidosqualene sterol cyclase.
Abstract An enzyme catalyzing the anaerobic cyclization of 2,3-oxidosqualene into lanosterol has been extracted from hog liver… Expand
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