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2,3-oxidosqualene

Known as: squalene-2,3-epoxide, 2,3-EDSQ, 2,3-epoxy-2,3-dihydrosqualene 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (1)

Squalene
analogs & derivatives

Narrower (2)

squalene monohydroperoxidesqualene peroxide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Divergent evolution of oxidosqualene cyclases in plants.
Triterpenes are one of the largest classes of plant metabolites and have important functions. A diverse array of triterpenoid… Expand
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Highly Cited
2008
Highly Cited
2008
Licorice β-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin
Glycyrrhizin, a major bioactive compound derived from the underground parts of Glycyrrhiza (licorice) plants, is a triterpene… Expand
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Highly Cited
2004
Highly Cited
2004
Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase
In higher organisms the formation of the steroid scaffold is catalysed exclusively by the membrane-bound oxidosqualene cyclase… Expand
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Review
2002
Review
2002
Biosynthesis of triterpenoid saponins in plants.
Many different plant species synthesise triterpenoid saponins as part of their normal programme of growth and development… Expand
Highly Cited
1997
Highly Cited
1997
Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin.
2,3-Oxidosqualene:lanosterol cyclase (OSC, E.C. 5.4.99.7) represents a unique target for a cholesterol lowering drug. Partial… Expand
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Highly Cited
1997
Highly Cited
1997
Structure and function of a squalene cyclase.
The crystal structure of squalene-hopene cyclase from Alicyclobacillus acidocaldarius was determined at 2.9 angstrom resolution… Expand
Highly Cited
1994
Highly Cited
1994
Isolation and characterization of the gene encoding 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae.
The ERG7 gene encoding oxidosqualene-lanosterol cyclase [(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol forming), EC 5.4.99… Expand
1992
1992
Inhibition of 2,3-oxidosqualene cyclases.
Monocyclic and tricyclic compounds possessing a nitrogen atom situated at a position corresponding to the carbenium ion of high… Expand
Highly Cited
1977
Highly Cited
1977
Yeast mutants deficient in heme biosynthesis and a heme mutant additionally blocked in cyclization of 2,3-oxidosqualene.
Mutants of Saccharomyces cerevisiae were isolated which were blocked in heme biosynthesis and required heme for growth on a… Expand
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Highly Cited
1967
Highly Cited
1967
A soluble 2,3-oxidosqualene sterol cyclase.
Abstract An enzyme catalyzing the anaerobic cyclization of 2,3-oxidosqualene into lanosterol has been extracted from hog liver… Expand
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