2,3-oxidosqualene

Known as: squalene-2,3-epoxide, 2,3-EDSQ, 2,3-epoxy-2,3-dihydrosqualene 
 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (1)

Squalene
analogs & derivatives

Narrower (2)

squalene monohydroperoxidesqualene peroxide

Papers overview

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2012
2012
Divergent evolution of oxidosqualene cyclases in plants.
Triterpenes are one of the largest classes of plant metabolites and have important functions. A diverse array of triterpenoid… (More)
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Highly Cited
2008
Highly Cited
2008
Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin.
Glycyrrhizin, a major bioactive compound derived from the underground parts of Glycyrrhiza (licorice) plants, is a triterpene… (More)
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Highly Cited
2004
Highly Cited
2004
Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase
In higher organisms the formation of the steroid scaffold is catalysed exclusively by the membrane-bound oxidosqualene cyclase… (More)
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Highly Cited
2002
Highly Cited
2002
A genomics approach to the early stages of triterpene saponin biosynthesis in Medicago truncatula.
The saponins of the model legume Medicago truncatula are glycosides of at least five different triterpene aglycones… (More)
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2001
2001
Potent anti-Trypanosoma cruzi activities of oxidosqualene cyclase inhibitors.
Trypanosoma cruzi is the protozoan agent that causes Chagas' disease, a major health problem in Latin America. Better drugs are… (More)
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1997
1997
Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo.
BIBB 515 (1-(4-chlorobenzoyl)-4-((4-(2-oxazolin-2-yl) benzylidene))piperidine) is a potent and selective inhibitor of 2,3… (More)
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1995
1995
2,3-oxidosqualene cyclase: From azasqualenes to new site-directed inhibitors
2,3-Oxidosqualene cyclases (OSC) are enzymes which convert 2,3-oxidosqualene (OS) into polycyclic triterpenoids such as… (More)
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1995
1995
Molecular cloning of cDNA encoding rat 2,3-oxidosqualene: lanosterol cyclase.
A cDNA encoding rat 2,3-oxidosqualene: lanosterol cyclase, the enzyme responsible for the complex cyclization/rearrangement step… (More)
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1992
1992
Purification of 2,3-oxidosqualene cyclase from rat liver.
A rapid and simple purification of milligram amounts of 2,3-oxidosqualene cyclase, an integral membrane enzyme that catalyzes the… (More)
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1977
1977
Yeast mutants deficient in heme biosynthesis and a heme mutant additionally blocked in cyclization of 2,3-oxidosqualene.
Mutants of Saccharomyces cerevisiae were isolated which were blocked in heme biosynthesis and required heme for growth on a… (More)
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