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2,3-oxidosqualene

Known as: squalene-2,3-epoxide, 2,3-EDSQ, 2,3-epoxy-2,3-dihydrosqualene 
 
National Institutes of Health

Papers overview

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2014
2014
Background: Pharmacological investigations position withanolides as important bioactive molecules demanding their copious… Expand
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Highly Cited
2012
Highly Cited
2012
Triterpenes are one of the largest classes of plant metabolites and have important functions. A diverse array of triterpenoid… Expand
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Highly Cited
2008
Highly Cited
2008
Glycyrrhizin, a major bioactive compound derived from the underground parts of Glycyrrhiza (licorice) plants, is a triterpene… Expand
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Highly Cited
2004
Highly Cited
2004
In higher organisms the formation of the steroid scaffold is catalysed exclusively by the membrane-bound oxidosqualene cyclase… Expand
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Highly Cited
2003
Highly Cited
2003
Abstract— Oxysterols are key regulators of lipid metabolism and regulate gene expression by activating the liver X receptor (LXR… Expand
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Highly Cited
1997
Highly Cited
1997
2,3-Oxidosqualene:lanosterol cyclase (OSC, E.C. 5.4.99.7) represents a unique target for a cholesterol lowering drug. Partial… Expand
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Highly Cited
1997
Highly Cited
1997
The crystal structure of squalene-hopene cyclase from Alicyclobacillus acidocaldarius was determined at 2.9 angstrom resolution… Expand
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Highly Cited
1996
Highly Cited
1996
Within the cholesterol biosynthesis cascade, the enzyme 2,3-oxidosqualene cyclase [EC 5.4.99.7] is of special interest due to its… Expand
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Highly Cited
1977
Highly Cited
1977
Mutants of Saccharomyces cerevisiae were isolated which were blocked in heme biosynthesis and required heme for growth on a… Expand
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Highly Cited
1967
Highly Cited
1967
Abstract An enzyme catalyzing the anaerobic cyclization of 2,3-oxidosqualene into lanosterol has been extracted from hog liver… Expand
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