18,19-dihydroetorphine

The thevinols and orvinols derived from thebaine via the thebaine-methylvinyl ketone adduct (thevinone) were thoroughly… Expand

In screening cytotoxic agents in morphine alkaloids [TE1-10], codeinone [TE8] was cytotoxic against two human oral tumor cells… Expand

This study examines the possibility that oripavine opioid receptor agonists bind equally to both high and low affinity states of… Expand

Neuropathic pain has been suggested to be resistant to treatment with opiates. Such perceived lack of opioid responsiveness may… Expand

Mu opioid receptors are subject to phosphorylation and desensitization through actions of at least two distinct biochemical… Expand

Comparative analgesic studies revealed that dihydroetorphine was more potent than etorphine in the tail-flick and hot-plate tests… Expand

We recently showed that the opioid alkaloids, etorphine, dihydroetorphine and diprenorphine, have remarkably potent antagonist… Expand

At low (< nM) concentrations, mu, delta or kappa opioid peptides as well as morphine and other opioid alkaloids elicit dose… Expand

The profile of actions of dihydroetorphine (DHE) concerning antinociception, tolerance and dependence was compared with those of… Expand

The analgesic, respiratory depressive, immobilizing effects and a cute toxicity of dihydroetorphine (DHE) have been evaluated and… Expand