18,19-dihydroetorphine

The thevinols and orvinols derived from thebaine via the thebaine-methylvinyl ketone adduct (thevinone) were thoroughly… Expand

In screening cytotoxic agents in morphine alkaloids [TE1-10], codeinone [TE8] was cytotoxic against two human oral tumor cells… Expand

To evaluate the pharmacokinetic and pharmacodynamic characteristics of a novel opioid analgesic, dihydroetorphine (DHE… Expand

Iatrogenic tolerance and physical dependence have been documented in human neonates and infants infused with fentanyl or morphine… Expand

This study examines the possibility that oripavine opioid receptor agonists bind equally to both high and low affinity states of… Expand

Neuropathic pain has been suggested to be resistant to treatment with opiates. Such perceived lack of opioid responsiveness may… Expand

Mu opioid receptors are subject to phosphorylation and desensitization through actions of at least two distinct biochemical… Expand

Comparative analgesic studies revealed that dihydroetorphine was more potent than etorphine in the tail-flick and hot-plate tests… Expand

These experiments examined whether dihydroetorphine (DHE) could serve as a reinforcer in rhesus monkeys and evoke the… Expand

At low (< nM) concentrations, mu, delta or kappa opioid peptides as well as morphine and other opioid alkaloids elicit dose… Expand