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17-(dimethylaminoethylamino)-17-demethoxygeldanamycin

Known as: 17-(dimethylaminoethylamino)-17-demethoxy-geldanamycin, 17-dimethylaminoethylamino-17-demethoxygeldanamycin, 17-dimethylaminoethylamino-17-demethoxy-geldanamycin 
An analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly… 
National Institutes of Health

Related topics

Related topics

8 relations
Alvespimycin HydrochlorideHSP90 Heat-Shock ProteinsNCIt Antineoplastic Agent TerminologySignal Transduction Inhibition

Broader (2)

BenzoquinonesLactams, Macrocyclic

Narrower (2)

KOS 1022NSC 707545

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Continuous water infusion enhances atmospheric pressure chemical ionization of methyl chloroformate derivatives in gas chromatography coupled to time-of-flight mass spectrometry-based metabolomics.
The effects of continuous water infusion on efficiency and repeatability of atmospheric pressure chemical ionization of both… 
2013
2013
The anticancer drug AUY922 generates a proteomics fingerprint that is highly conserved among structurally diverse Hsp90 inhibitors.
AUY922 is a potent synthetic Hsp90 antagonist that is moving steadily through clinical trials against a small range of cancers… 
2013
2013
An activated JAK/STAT3 pathway and CD45 expression are associated with sensitivity to Hsp90 inhibitors in multiple myeloma.
2013
2013
Inhibiting proliferation of gefitinib-resistant, non-small cell lung cancer
PurposeSensitivity to a tyrosine kinase inhibitor (TKI) is correlated with the presence of somatic mutations that affect the… 
Review
2011
Review
2011
Heat Shock Protein as Molecular Targets for Breast Cancer Therapeutics
Recent advances in the understanding of the molecular mechanisms involved in the breast cancer development and progression have… 
2011
2011
Active Participation of Cellular Chaperone Hsp90 in Regulating the Function of Rotavirus Nonstructural Protein 3 (NSP3)*
Heat shock protein 90 (Hsp90) has been reported to positively regulate rotavirus replication by modulating virus induced PI3K/Akt… 
2007
2007
Phase I trial of alvespimycin (KOS-1022; 17-DMAG) and trastuzumab (T)
1115 Background: Alvespimycin (A) inhibits the activity of Hsp90, resulting in degradation of client proteins, such as the HER2… 
2006
2006
Synergistic Interactions between DMAG and Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitors in Bcr/abl+ Leukemia Cells Sensitive and Resistant to Imatinib Mesylate
Purpose: To characterize interactions between the heat shock protein 90 antagonist 17-dimethylaminoethylamino-17… 
2005
2005
Structure-based design of 7-carbamate analogs of geldanamycin.
2003
2003
Filter binding assay for the geldanamycin-heat shock protein 90 interaction.
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