17-(dimethylaminoethylamino)-17-demethoxygeldanamycin

Known as: 17-(dimethylaminoethylamino)-17-demethoxy-geldanamycin, 17-dimethylaminoethylamino-17-demethoxygeldanamycin, 17-dimethylaminoethylamino-17-demethoxy-geldanamycin 
An analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly… (More)
National Institutes of Health

Papers overview

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2013
2013
Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disease currently with no treatment… (More)
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2012
2012
Despite the increasing importance of heat shock protein 90 (Hsp90) inhibitors as chemotherapeutic agents in diseases such as… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE A phase I study to define toxicity and recommend a phase II dose of the HSP90 inhibitor alvespimycin (17-DMAG; 17… (More)
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2010
2010
AIMS Heat shock protein 90 (HSP90) is a ubiquitous chaperone involved in the folding, activation, and assembly of many proteins… (More)
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Highly Cited
2007
Highly Cited
2007
Whether cancer stem cells occur in BRCA1-associated breast cancer and contribute to therapeutic response is not known. We… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE Inhibitors of heat-shock protein 90 (Hsp90) may interfere with oncogenic signaling pathways, including Erk, Akt, and… (More)
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Highly Cited
2007
Highly Cited
2007
Oncogenic signaling through activation of epidermal growth factor receptor (EGFR), HER-2, and hypoxia inducible-factor-1alpha… (More)
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Highly Cited
2006
Highly Cited
2006
Inhibitors of the molecular chaperone Hsp90 have been shown to enhance tumor cell radiosensitivity. To begin to address the… (More)
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Highly Cited
2004
Highly Cited
2004
The ansamycin antibiotic, geldanamycin, targets the hsp 90 protein chaperone and promotes ubiquitin-dependent proteasomal… (More)
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Highly Cited
2001
Highly Cited
2001
Purpose: 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin (17DMAG) is an analogue of the benzoquinone ansamycin compound 17… (More)
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