FAQ

15-Hydroxyprostaglandin dehydrogenase (NAD+)

Known as: prostaglandin-15-hydroxydehydrogenase, 15-ketoprostaglandin reductase, 15-PGDH 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1977-2017
01219772017

Related topics

Related topics

4 relations

Narrower (1)

15-Hydroxyprostaglandin Dehydrogenase [NAD+], human
HPGD geneHPGD wt Allele

Broader (1)

Hydroxyprostaglandin Dehydrogenases

Related mentions per year

Related mentions per year

1975-2018
197019801990200020102020
15-Hydroxyprostaglandin dehydrogenase (NAD+)
HPGD gene
15-Hydroxyprostaglandin Dehydrogenase [NAD+], human
HPGD wt Allele
Hydroxyprostaglandin Dehydrogenases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
miR-21 modulates prostaglandin signaling and promotes gastric tumorigenesis by targeting 15-PGDH.
miR-21 is an abundantly expressed miRNA in mammalian cells, and evolutionarily conserved across a wide range of vertebrate… (More)
Is this relevant?
2014
2014
Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD).
Aspirin use reduces the risk of colorectal neoplasia, at least in part, through inhibition of prostaglandin-endoperoxide synthase… (More)
  • table 1
  • table 2
Is this relevant?
2014
2014
miR-21 targets 15-PGDH and promotes cholangiocarcinoma growth.
UNLABELLED miRNAs are a group of small, noncoding RNAs that modulate the translation of genes by binding to specific target sites… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2014
2014
Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.
The structure-activity relationship (SAR) study of two chemotypes identified as inhibitors of the human NAD(+)-dependent 15… (More)
Is this relevant?
2014
2014
Hypoxia activates 15-PGDH and its metabolite 15-KETE to promote pulmonary artery endothelial cells proliferation via ERK1/2 signalling.
BACKGROUND AND PURPOSE Dysfunction and injury of endothelial cells in the pulmonary artery play critical roles in the… (More)
Is this relevant?
2010
2010
High-Affinity Inhibitors of Human NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships
BACKGROUND 15-Hydroxyprostaglandin dehydrogenase (15-PGDH, EC 1.1.1.141) is the key enzyme for the inactivation of prostaglandins… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
2010
2010
Radiation Inhibits 15-Hydroxyprostaglandin ydrogenase Levels in Human Skin: Evidence
ownloade ated levels of prostaglandins (PG) have been detected in the skin following UV radiation (UVR). lay an important role in… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
1987
1987
Partial purification of prostaglandin E2-9-ketoreductase and prostaglandin-15-hydroxydehydrogenase from ovarian tissues of rabbits.
Prostaglandin E2-9-ketoreductase (PGE2-9-KR) and prostaglandin-15-hydroxydehydrogenase (PG-15-HDH) have been purified 25.0- and… (More)
Is this relevant?
1986
1986
The influence of continuous intrauterine infusion of enzyme-inhibitors of the arachidonic acid cascade on ovulation and tubal ovum transport in the hyperstimulated rabbit.
Cyclo-oxygenase and prostaglandin-15-hydroxydehydrogenase are rate-limiting steps in the arachidonic acid cascade. These enzymes… (More)
Is this relevant?
1977
1977
Multiple molecular forms of prostaglandin 15-hydroxydehydrogenase and 9-ketoreductase in chicken kidney.
Prostaglandin-15-hydroxydehydrogenase and prostaglandin-9-keto-reductase were purified from chicken kidney. Both enzymes exist in… (More)
Is this relevant?