13-deoxytedanolide
National Institutes of Health
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13-Deoxytedanolide is a structurally unique macrolide with strong antitumor activity isolated from a marine sponge. Recently, we…
A total synthesis of 13-deoxytedanolide is described. The synthesis features a highly stereoselective fragment assembly aldol…
Tedanolide is a 18-membered macrolide of marine origin which displays antitumor activity and presents a synthetic challenge. To…
[reaction: see text] The nonaldol aldol process developed in our laboratories has been applied to the synthesis of a C(1)-C(11…
[formula: see text] In this Letter we describe a synthetic strategy and an efficient assembly of a common C(1)-C(11) subtarget…