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13,14-dehydroprostaglandin I2 methyl ester

Known as: 13,14-dehydroprostacyclin methyl ester, 13,14-dehydro PGI2 methyl ester, prost-5-en-13-yn-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, methyl ester, (5Z,9 alpha,11 alpha,15S)- 
 
National Institutes of Health

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2 relations

Broader (1)

Epoprostenol
analogs & derivatives

Papers overview

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2015
2015
A vasoconstrictor response to COX-1-mediated prostacyclin synthesis in young rat renal arteries that increases in prehypertensive conditions.
This study aimed to determine whether prostacyclin (PGI2) functions as an endothelium-derived contracting factor (EDCF) in young… Expand
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1990
1990
Process for the preparation of 5,6,7-trinor-4,8-inter-m-phenylene PGI2 derivatives
 
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1989
1989
Process for the preparation of pharmacologically active 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 derivative as intermediate
 
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1984
1984
Structure-activity relationship (SAR) among prostacyclin (PGI2) analogues.
The main aims of the research for new PGI2 analogues are to increase (1) the duration of action and/or (2) biological selectivity… Expand
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1983
1983
Positive inotropic effect of a stable analogue of PGI2 and of PGI2 on isolated guinea pig atria. Mechanism of action.
Fluoroprostacyclin (10,10-difluoro-13,14-dehydroprostacyclin) a stable analogue of PGI2, induced an increase of contractile… Expand
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1982
1982
Low concentrations of prostaglandin E2 inhibit the prostacyclin-induced elevation of cyclic adenosine 3',5'-monophosphate in elicited populations of rat peritoneal macrophages.
Elevation of cyclic adenosine 3',5'-monophosphate (cyclic AMP) in elicited populations of rat peritoneal macrophages was used as… Expand
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1978
1978
Coronary vasodilator activity of 13,14-dehydroprostacyclin methyl ester: comparison with prostacyclin and other prostanoids.
The effects of a recently synthesized, stable prostacyclin (PGI2) analog, 13,14-dehydro-PGI2 methyl ester, and authentic PGI2 and… Expand
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1977
1977
Unusual pulmonary vasodilator activity of 13,14-dehydroprostacyclin methyl ester: comparison with endoperoxides and other prostanoids.
Microsomes from stomach fundus and blood vessels transform the endoperoxide, PGH2, into a newly discovered unstable substance… Expand
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