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13,14-dehydroprostaglandin I2 methyl ester

Known as: 13,14-dehydroprostacyclin methyl ester, 13,14-dehydro PGI2 methyl ester, prost-5-en-13-yn-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, methyl ester, (5Z,9 alpha,11 alpha,15S)- 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Epoprostenol
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
A vasoconstrictor response to COX-1-mediated prostacyclin synthesis in young rat renal arteries that increases in prehypertensive conditions.
This study aimed to determine whether prostacyclin (PGI2) functions as an endothelium-derived contracting factor (EDCF) in young… Expand
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1990
1990
Process for the preparation of 5,6,7-trinor-4,8-inter-m-phenylene PGI2 derivatives
 
1989
1989
Process for the preparation of pharmacologically active 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 derivative as intermediate
 
1984
1984
Structure-activity relationship (SAR) among prostacyclin (PGI2) analogues.
The main aims of the research for new PGI2 analogues are to increase (1) the duration of action and/or (2) biological selectivity… Expand
1983
1983
Positive inotropic effect of a stable analogue of PGI2 and of PGI2 on isolated guinea pig atria. Mechanism of action.
Fluoroprostacyclin (10,10-difluoro-13,14-dehydroprostacyclin) a stable analogue of PGI2, induced an increase of contractile… Expand
1982
1982
LOW CONCENTRATIONS OF PROSTAGLANDIN E2 INHIBIT THE PROSTACYCLIN‐INDUCED ELEVATION OF CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE IN ELICITED POPULATIONS OF RAT PERITONEAL MACROPHAGES
1 Elevation of cyclic adenosine 3′,5′‐monophosphate (cyclic AMP) in elicited populations of rat peritoneal macrophages was used… Expand
1978
1978
Coronary vasodilator activity of 13,14-dehydroprostacyclin methyl ester: comparison with prostacyclin and other prostanoids.
The effects of a recently synthesized, stable prostacyclin (PGI2) analog, 13,14-dehydro-PGI2 methyl ester, and authentic PGI2 and… Expand
1977
1977
Unusual pulmonary vasodilator activity of 13,14-dehydroprostacyclin methyl ester: comparison with endoperoxides and other prostanoids.
Microsomes from stomach fundus and blood vessels transform the endoperoxide, PGH2, into a newly discovered unstable substance… Expand
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