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12-deoxyphorbolphenylacetate-20-acetate

Known as: 12-DOPPAA, 12-deoxyphorbol 13-phenylacetate 20-acetate 
National Institutes of Health

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Phorbol Esters

Papers overview

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2006
2006
Chronic PKC-beta2 activation in HT-29 Cl.19a colonocytes prevents cAMP-mediated ion secretion by inhibiting apical membrane CFTR targeting.
We investigated the effects of chronically applied PKC-stimulating phorbol esters on subcellular CFTR expression and localization… 
Highly Cited
1998
Highly Cited
1998
Protein Kinase Cδ-dependent Induction of Manganese Superoxide Dismutase Gene Expression by Microtubule-active Anticancer Drugs*
Bacterial lipopolysaccharide can induce manganese superoxide dismutase (MnSOD) gene expression in a variety of cells. Paclitaxel… 
1997
1997
Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells
In a previous study, we showed that geranylgeraniol (GGO) is a potent inducer of apoptosis in human leukemia cells, including… 
1997
1997
Regulation of thymocyte lineage commitment by the level of classical protein kinase C activity.
Thymocyte-positive selection involves signaling through TCR and accessory molecules, and the signaling intensity appears to be… 
1997
1997
Human umbilical vein and dermal microvascular endothelial cells show heterogeneity in response to PKC activation.
Changes in endothelial cell (EC) phenotype are central to the function of endothelium in inflammation. Although these events… 
1996
1996
Activation of conventional mammalian protein kinase C isoforms expressed in budding yeast modulates the cell doubling time--a potential in vivo screen for protein kinase C activators.
Conventional mammalian protein kinase C (PKC) isoforms alpha, beta 1, and gamma were expressed in Saccharomyces cerevisiae and… 
1995
1995
Pro‐transforming growth factor‐alpha processing in human colon carcinoma cells: Role of protein kinase C
The human colon cancer cell lines HCT 116 (poorly differentiated) and CEO (well differentiated) express the mitogenic peptide… 
1994
1994
Stimulation of protein kinase C activity may increase microvascular permeability to colloidal carbon viaα-isoenzyme
The vasculature of the isolated mesentery and small intestine was perfused with a gelatin-containing physiological salt solution… 
1993
1993
A protein kinase C agonist, selective for the beta I isozyme, induces E-selectin and VCAM-1 expression on HUVEC but does not translocate PKC.
A protein kinase C (PKC) agonist selective for the beta I isozyme, 12-deoxyphorbol 13-phenylacetate 20-acetate (dPPA), induced NF… 
1990
1990
Platelet protein phosphorylation and protein kinase C activation by phorbol esters with different biological activity and a novel synergistic response with Ca2+ ionophore.
Phorbol esters with different biological activities have been tested for their ability to induce the phosphorylation of human… 
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