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11-ketodihydrotestosterone

 
National Institutes of Health

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2 relations

Broader (1)

Testosterone
analogs & derivatives

Papers overview

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2020
2020
Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C19-steroids
Recent studies have shown that an adrenal steroid 11β-hydroxy-4-androstene-3,17-dione serves as the precursor to androgens, 11… Expand
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Review
2020
Review
2020
11-Oxygenated androgens in health and disease
The adrenal gland is a source of sex steroid precursors, and its activity is particularly relevant during fetal development and… Expand
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2018
2018
The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway
Increased circulating 11β-hydroxyprogesterone (11OHP4), biosynthesised in the human adrenal, is associated with 21-hydroxylase… Expand
Is this relevant?
Review
2017
Review
2017
A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids
The abundant adrenal C19 steroid 11β-hydroxyandrostenedione (11OHA4) has been written off as a dead-end product of adrenal… Expand
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Review
2017
Review
2017
Clinical significance of 11-oxygenated androgens
Purpose of review The adrenal gland is considered a source of weak androgens, such as dehydroepiandrosterone… Expand
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2016
2016
High-throughput analysis of 19 endogenous androgenic steroids by ultra-performance convergence chromatography tandem mass spectrometry.
11-Oxygenated steroids such as 11-ketotestosterone and 11-ketodihydrotestosterone have recently been shown to play a putative… Expand
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2016
2016
An investigation into the androgenic activity of 11-ketotestosterone and 11-ketodihydrotestosterone
 
Is this relevant?
Review
2015
Review
2015
11β-hydroxyandrostenedione: Downstream metabolism by 11βHSD, 17βHSD and SRD5A produces novel substrates in familiar pathways
11β-Hydroxyandrostenedione (11OHA4), a major C19 steroid produced by the adrenal, was first reported in the 1950s. Initially the… Expand
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2013
2013
11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: A putative role in castration resistant prostate cancer?
Adrenal C19 steroids, dehydroepiandrostenedione (DHEA(S)) and androstenedione (A4), play a critical role in castration resistant… Expand
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2013
2013
b-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone , novel C 19 steroids with androgenic activity : A putative role in castration resistant prostate cancer ?
Adrenal C19 steroids, dehydroepiandrostenedione (DHEA(S)) and androstenedione (A4), play a critical role in castration resistant… Expand
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