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11-beta-Hydroxysteroid Dehydrogenase Type 1

Known as: 11beta HSD1 Reductase, 11beta-HSD1 Reductase, 11beta Hydroxysteroid Dehydrogenase Type 1 
A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue… Expand
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
The identification of small molecules that fall within the biologically relevant subfraction of vast chemical space is of utmost… Expand
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Highly Cited
2004
Highly Cited
2004
The metabolic syndrome (visceral obesity, insulin resistance, type 2 diabetes, and dyslipidemia) resembles Cushing's Syndrome… Expand
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Highly Cited
2004
Highly Cited
2004
In obese humans and rodents there is increased expression of the key glucocorticoid (GC) regenerating enzyme, 11beta… Expand
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Highly Cited
2003
Highly Cited
2003
11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) has been proposed as a new target for type 2 diabetes drugs. The aim… Expand
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Highly Cited
2003
Highly Cited
2003
Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes… Expand
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Highly Cited
2002
Highly Cited
2002
Cushing's syndrome and the metabolic syndrome share clinical similarities. Reports of alterations in the hypothalamic-pituitary… Expand
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Highly Cited
2001
Highly Cited
2001
The adverse metabolic consequences of obesity are best predicted by the quantity of visceral fat. Excess glucocorticoids produce… Expand
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Highly Cited
2001
Highly Cited
2001
Cortisol has been implicated as a pathophysiological mediator in idiopathic obesity, but circulating cortisol concentrations are… Expand
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Highly Cited
2001
Highly Cited
2001
Excess tissue glucocorticoid action may underlie the dyslipidemia, insulin resistance, and impaired glucose tolerance of the… Expand
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Highly Cited
1997
Highly Cited
1997
Glucocorticoid hormones, acting via nuclear receptors, regulate many metabolic processes, including hepatic gluconeogenesis. It… Expand
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