11-beta-Hydroxysteroid Dehydrogenase Type 1

Known as: 11beta HSD1 Reductase, 11beta-HSD1 Reductase, 11beta Hydroxysteroid Dehydrogenase Type 1 
A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue… (More)
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
The local generation of active glucocorticoid by NADPH-dependent, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1… (More)
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Highly Cited
2006
Highly Cited
2006
Glucocorticoids promote macrophage phagocytosis of leukocytes undergoing apoptosis. Prereceptor metabolism of glucocorticoids by… (More)
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Highly Cited
2005
Highly Cited
2005
Two isozymes of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) interconvert active cortisol and inactive cortisone. 11 beta… (More)
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Highly Cited
2004
Highly Cited
2004
The metabolic syndrome (visceral obesity, insulin resistance, type 2 diabetes, and dyslipidemia) resembles Cushing's Syndrome… (More)
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Highly Cited
2004
Highly Cited
2004
In obese humans and rodents there is increased expression of the key glucocorticoid (GC) regenerating enzyme, 11beta… (More)
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Highly Cited
2003
Highly Cited
2003
11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) has been proposed as a new target for type 2 diabetes drugs. The aim… (More)
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Highly Cited
2003
Highly Cited
2003
Metabolic effects of cortisol may be critically modulated by glucocorticoid metabolism in tissues. Specifically, active cortisol… (More)
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Highly Cited
2002
Highly Cited
2002
As exemplified in patients with Cushing's syndrome, glucocorticoids play an important role in regulating adipose tissue… (More)
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2001
2001
11beta-hydroxysteroid dehydrogenases (11beta-HSD) perform prereceptor metabolism of glucocorticoids through interconversion of… (More)
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2000
2000
Obesity has been associated with alterations in glucocorticoid metabolism in both man and rodents, but the underlying mechanisms… (More)
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