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11-beta-Hydroxysteroid Dehydrogenase Type 1

Known as: 11beta HSD1 Reductase, 11beta-HSD1 Reductase, 11beta Hydroxysteroid Dehydrogenase Type 1 
A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue… 
National Institutes of Health

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In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Papers overview

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Highly Cited
2008
Highly Cited
2008
Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice.
Intracellular glucocorticoid (GC) receptor (GR) function determines tissue sensitivity to GCs and strongly affects the… 
2008
2008
Lack of hexose-6-phosphate dehydrogenase impairs lipid mobilization from mouse adipose tissue.
In adipose tissue, glucocorticoids regulate lipogenesis and lipolysis. Hexose-6-phosphate dehydrogenase (H6PDH) is an enzyme… 
Review
2007
Review
2007
Readjusting the glucocorticoid balance: an opportunity for modulators of 11beta-hydroxysteroid dehydrogenase type 1 activity?
Glucocorticoids play a pivotal role in the regulation of most essential physiological processes, including energy metabolism… 
Review
2005
Review
2005
Maternal nutritional programming of fetal adipose tissue development: long-term consequences for later obesity.
As obesity reaches epidemic levels in the United States there is an urgent need to understand the developmental pathways leading… 
Highly Cited
2005
Highly Cited
2005
Expression of 11beta-hydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells.
Glucocorticoids (GCs) exert powerful anti-inflammatory effects that may relate in part to their ability to restrict the… 
2005
2005
0021-972X/05/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 90(7):3919–3926 Printed in U.S.A. Copyright © 2005 by The Endocrine Society doi: 10.1210/jc.2004-2390 Obesity and Type 2…
  • 2005
  • Corpus ID: 11692312
Review
2004
Review
2004
11beta-hydroxysteroid dehydrogenase type 1 as a modulator of glucocorticoid action: from metabolism to memory.
Increases in plasma cortisol and glucocorticoid pharmacotherapy cause myriad adverse effects from obesity and diabetes to… 
Highly Cited
2004
Highly Cited
2004
Enantioselectivity of carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone by tissue fractions from human and rat and by enzymes isolated from human liver.
Detoxication of the tobacco-specific carcinogen 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in humans is mainly due to… 
2004
2004
Appropriate Function of 11β-Hydroxysteroid Dehydrogenase Type 1 in the Endoplasmic Reticulum Lumen Is Dependent on Its N-terminal Region Sharing Similar Topological Determinants with 50-kDa Esterase*
By interconverting glucocorticoids, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) exerts an important pre-receptor function… 
1997
1997
Differential regulation of 11 beta-hydroxysteroid dehydrogenase type 1 and 2 by nitric oxide in cultured human placental trophoblast and chorionic cell preparation.
Two types of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) have been identified in different tissues. Type 1 has both… 
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