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1-methylxanthine

National Institutes of Health

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Xanthines

Papers overview

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2010
2010
Loss of insulin‐mediated microvascular perfusion in skeletal muscle is associated with the development of insulin resistance
Aim: The aetiology of the development of type 2 diabetes remains unresolved. In the present study, we assessed whether an… 
Highly Cited
2005
Highly Cited
2005
POSSIBLE INVOLVEMENT OF ORGANIC ANION TRANSPORTER 2 ON THE INTERACTION OF THEOPHYLLINE WITH ERYTHROMYCIN IN THE HUMAN LIVER
Organic anion transporter 2 (Oat2 [SLC22A7]) is a multispecific organic anion transporter. Although several substrates of human… 
Highly Cited
2003
Highly Cited
2003
TNF-α acutely inhibits vascular effects of physiological but not high insulin or contraction
TNF-α is elevated in many states of insulin resistance, and acutely administered TNF-α in vivo inhibits insulin-mediated… 
2002
2002
Severe 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) intoxication: Insights into the measurement of hepatic cytochrome P450 1A2 induction *
The correct in vivo quantification of aryl hydrocarbon receptor‐mediated induction of cytochrome P450 1A2 (CYP1A2) in humans is a… 
2001
2001
Use of novel solid-phase extraction sorbent materials for high-performance liquid chromatography quantitation of caffeine metabolism products methylxanthines and methyluric acids in samples of…
Highly Cited
1998
Highly Cited
1998
Analysis of urinary caffeine metabolites to assess biotransformation enzyme activities by reversed-phase high-performance liquid chromatography.
  • C. KrulG. Hageman
  • Journal of Chromatography B: Biomedical Sciences…
  • 1998
  • Corpus ID: 24465441
1994
1994
Screening for hydroxylation and acetylation polymorphisms in man via simultaneous analysis of urinary metabolites of mephenytoin, dextromethorphan and caffeine by capillary electrophoretic procedures…
Highly Cited
1988
Highly Cited
1988
Caffeine and theophylline metabolism in newborn and adult human hepatocytes; comparison with adult rat hepatocytes.
Review
1976
Review
1976
Theophylline metabolism by the rat liver microsomal system.
The metabolism of 8-14C-theophylline (14C-Theo) was investigated in vivo and in vitro in the rat. In vivo, 14C-Theo at an initial… 
Highly Cited
1975
Highly Cited
1975
Biosynthesis of caffeine by tea-leaf extracts. Enzymic formation of theobromine from 7-methylxanthine and of caffeine from theobromine.
1. Extracts prepared from tea leaves with Polyclar AT (insoluble polyvinylpyrrolidine) contained two methyltransferase activities… 
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