1-hydroxymethylmidazolam

Known as: 1-OH-MDZ, 1-Hydroxymidazolam, alpha-hydroxymidazolam 
 
National Institutes of Health

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Highly Cited
2007
Highly Cited
2007
PURPOSE To examine the enzyme kinetics of gefitinib and erlotinib metabolism by individual cytochrome P450 (CYP) enzymes, and to… (More)
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Highly Cited
2005
Highly Cited
2005
OBJECTIVES Elderly patients are more likely to ingest prescription medications concurrently with botanical supplements, and may… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVES Phytochemical-mediated modulation of cytochrome P450 (CYP) activity may underlie many herb-drug interactions. Single… (More)
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Highly Cited
2002
Highly Cited
2002
OBJECTIVES Phytochemical-mediated modulation of cytochrome P450 (CYP) activity may underlie many herb-drug interactions. Single… (More)
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Highly Cited
1998
Highly Cited
1998
OBJECTIVE To assess the relative contribution of intestinal and hepatic CYP3A inhibition to the interaction between the… (More)
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Highly Cited
1997
Highly Cited
1997
The human colon carcinoma cell line, Caco-2, is widely used as a model for oral absorption of xenobiotics. The usefulness of Caco… (More)
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Highly Cited
1996
Highly Cited
1996
OBJECTIVE To determine in humans the relative roles of intestinal and hepatic metabolism in the oral first-pass elimination of a… (More)
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Highly Cited
1996
Highly Cited
1996
The in vivo intestinal metabolism of the CYP3A probe midazolam to its principal metabolite, 1'-hydroxymidazolam, was investigated… (More)
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Highly Cited
1996
Highly Cited
1996
It has been proposed that excessive intrarenal conversion of cortisol to 6 beta-hydroxycortisol by CYP3A may mediate increased… (More)
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Highly Cited
1994
Highly Cited
1994
The capabilities of cytochrome P4503A4 (CYP3A4), CYP3A5, and fetal hepatic microsomes containing CYP3A7 to metabolize midazolam… (More)
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