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1-deoxy-D-xylulose-5-phosphate synthase

Known as: 1-deoxy-D-xylulose-5-phosphatase, DXP synthase, deoxyxylulose-5-phosphate synthase 
 
National Institutes of Health

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1 relation

Broader (1)

Transferase

Papers overview

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2017
2017
Investigations into the Non-Mevalonate Isoprenoid Biosynthesis Pathway's First Two Enzymes utilizing Hybrid QM/MM Techniques
Molecular drug design begins with the identification of a problem to solve. This work identifies the growing resistance among… Expand
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2015
2015
Hydroxybenzaldoximes Are D-GAP-Competitive Inhibitors of E. coli 1-Deoxy-D-Xylulose-5-Phosphate Synthase.
1-Deoxy-D-xylulose 5-phosphate (DXP) synthase is the first enzyme in the methylerythritol phosphate pathway to essential… Expand
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2015
2015
Enhancing Terpene yield from sugars via novel routes to 1-deoxy-d-xylulose 5-phosphate.
Terpene synthesis in the majority of bacterial species, together with plant plastids, takes place via the 1-deoxy-d-xylulose 5… Expand
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2014
2014
Defining critical residues for substrate binding to 1-deoxy-D-xylulose 5-phosphate synthase--active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate.
1-Deoxy-D-xylulose 5-phosphate (DXP) synthase catalyzes the formation of DXP from pyruvate and D-glyceraldehyde 3-phosphate (GraP… Expand
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2013
2013
Functional and evolutionary analysis of DXL1, a non-essential gene encoding a 1-deoxy-D-xylulose 5-phosphate synthase like protein in Arabidopsis thaliana.
The synthesis of 1-deoxy-D-xylulose 5-phosphate (DXP), catalyzed by the enzyme DXP synthase (DXS), represents a key regulatory… Expand
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2013
2013
DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design.
1-Deoxy-D-xylulose 5-phosphate (DXP) synthase catalyzes the first step in the nonmammalian isoprenoid biosynthetic pathway to… Expand
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2012
2012
Mutations in Escherichia coli aceE and ribB Genes Allow Survival of Strains Defective in the First Step of the Isoprenoid Biosynthesis Pathway
A functional 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway is required for isoprenoid biosynthesis and hence survival in… Expand
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Highly Cited
2001
Highly Cited
2001
1-Deoxy-D-xylulose 5-phosphate reductoisomerase and plastid isoprenoid biosynthesis during tomato fruit ripening.
The recently discovered 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for the biosynthesis of plastid isoprenoids (including… Expand
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Highly Cited
2000
Highly Cited
2000
Evidence of a role for LytB in the nonmevalonate pathway of isoprenoid biosynthesis.
It is proposed that the lytB gene encodes an enzyme of the deoxyxylulose-5-phosphate (DOXP) pathway that catalyzes a step at or… Expand
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