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1-(2-pyrimidinyl)piperazine

National Institutes of Health

Papers overview

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2002
2002
The objective of this investigation was to compare the in vivo potency and intrinsic activity of buspirone and its metabolite 1… Expand
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1997
1997
It has been suggested that in vivo formation of the metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) may be a major drawback in the… Expand
1992
1992
Using a standard two-lever operant procedure with rats trained to discriminate 1-(3-trifluoromethylphenyl)piperazine (TFMPP) (0.5… Expand
1992
1992
A selective and sensitive high-performance liquid chromatographic method with coulometric detection is described for the… Expand
1990
1990
The effect of 1-(2-pyrimidinyl)piperazine (PmP), the main metabolite of buspirone, was tested on K(+)-evoked [3H]noradrenaline… Expand
1990
1990
The effects of systemically administered ipsapirone, an aryl-piperazine compound, and its major metabolite 1-(2-pyrimidinyl… Expand
Highly Cited
1989
Highly Cited
1989
  • R. Fuller, K. Perry
  • The Journal of pharmacology and experimental…
  • 1989
  • Corpus ID: 24981907
Buspirone, an anxiolytic drug with selective affinity for the 5-HT-1A subtype of serotonin receptors, caused a dose-related… Expand
1989
1989
It was found that gepirone and 1-(2-pyrimidinyl)-piperazine (1-PP) increased levels of corticosterone in plasma in the intact rat… Expand
Review
1986
Review
1986
Buspirone hydrochloride (HCl)1 is a new anxiolytic with a unique chemical structure. Its mechanism of action remains to be… Expand
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Highly Cited
1983
Highly Cited
1983
After i.v. injection (10 mg/kg) to rats, buspirone is rapidly cleared from blood with a t1/2 (beta) or 30 min. After the same… Expand