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1-(2-pyrimidinyl)piperazine

 
National Institutes of Health

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2002
2002
The objective of this investigation was to compare the in vivo potency and intrinsic activity of buspirone and its metabolite 1… Expand
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1998
1998
Abstract Biotransformation of gepirone to its principal metabolite, 1-(2-pyrimidinyl)-piperazine (1-PP), was studied in human… Expand
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1997
1997
It has been suggested that in vivo formation of the metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) may be a major drawback in the… Expand
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1992
1992
Using a standard two-lever operant procedure with rats trained to discriminate 1-(3-trifluoromethylphenyl)piperazine (TFMPP) (0.5… Expand
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1992
1992
Tandospirone is an azaspirodecanedione derivative under investigation as an antidepressant. Metabolism of tandospirone in humans… Expand
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1990
1990
The effect of 1-(2-pyrimidinyl)piperazine (PmP), the main metabolite of buspirone, was tested on K(+)-evoked [3H]noradrenaline… Expand
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1990
1990
The effects of systemically administered ipsapirone, an aryl-piperazine compound, and its major metabolite 1-(2-pyrimidinyl… Expand
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1989
1989
Buspirone, an anxiolytic drug with selective affinity for the 5-HT-1A subtype of serotonin receptors, caused a dose-related… Expand
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1989
1989
Pyrimidinylpiperazine anxiolytic drugs-ipsapirone, buspirone and gepirone-dose- dependently increased punished responding in an… Expand
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1983
1983
After i.v. injection (10 mg/kg) to rats, buspirone is rapidly cleared from blood with a t1/2 (beta) or 30 min. After the same… Expand
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