1,5-dimethylbarbituric acid
National Institutes of Health
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In vitro studies with human liver preparations suggest that the metabolism of hexobarbital involves CYP2CMP--the determinant of…
1. In the presence of glutathione under physiological conditions, 3'-oxohexobarbital was non-enzymically converted to 1,5…
A highly sensitive and specific assay based on gas chromatography/electron capture negative ion chemical ionization mass…
SummaryThe pharmacokinetics in blood of the major metabolites of hexobarbital (HB), 3′-hydroxyhexobarbital (OH-HB) and 3…
Two model substrates for oxidative hepatic enzyme activity, viz. hexobarbital (HB) and antipyrine (AP), were given simultaneously…
The enantiomers of hexobarbital (HB), designated as (+)-HB and (-)-HB, were administered orally to separate groups of rats. Blood…
1 Hexobarbitone plasma kinetics were determined in six healthy volunteers, who received 500 mg hexobarbitone orally. In addition…
1. In urine of rats treated with 1',2'-epoxyhexobarbital, unchanged compound and six metabolites were identified: 1,5…