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1,5-benzothiazepine
National Institutes of Health
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1 relation
Broader (1)
Thiazepines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Facile net cycloaddition approach to optically active 1,5-benzothiazepines.
Yukihiro Fukata
,
Keisuke Asano
,
S. Matsubara
Journal of the American Chemical Society
2015
Corpus ID: 7455904
The 1,5-benzothiazepine moiety is well-known as a versatile pharmacophore, and its derivatives are expected to have antagonism…
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2009
2009
Synthesis and biological evaluation of a novel series of 1,5-benzothiazepine derivatives as potential antimicrobial agents.
L. Wang
,
P. Zhang
,
X. Zhang
,
Y. Zhang
,
Y. Li
,
Yongxiang Wang
European journal of medicinal chemistry
2009
Corpus ID: 19919022
Two series of novel 1,5-benzothiazepine derivatives (23 compounds) were efficiently synthesized and evaluated for antibacterial…
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1991
1991
Synthesis of halogen-substituted 1,5-benzothiazepine derivatives and their vasodilating and hypotensive activities.
H. Inoue
,
M. Konda
,
+7 authors
S. Murata
Journal of medicinal chemistry
1991
Corpus ID: 35733103
In an attempt to improve the effectiveness and duration of the action of diltiazem (1), a 1,5-benzothiazepine calcium channel…
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1988
1988
Calcium antagonistic and spasmolytic activities of a new 1,5-benzothiazepine derivative in isolated canine and monkey arteries.
K. Kikkawa
,
S. Murata
,
T. Nagao
Arzneimittel-Forschung
1988
Corpus ID: 37485368
Effects of TA-3090 ((+) (2S,3S)-3-acetoxy-8-chloro-5-(2-(dimethylamino)ethyl)-2, 3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin…
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1986
1986
Synthesis and angiotensin converting enzyme inhibitory activity of 1,5-benzothiazepine and 1,5-benzoxazepine derivatives. I.
K. Itoh
,
M. Kori
,
Y. Inada
,
K. Nishikawa
,
Y. Kawamatsu
,
H. Sugihara
Chemical & pharmaceutical bulletin
1986
Corpus ID: 45289920
A seires of (R)-3-amino-4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzothiazepine-5-acetic acids (8) and (S)-3-amino-4-oxo-2, 3, 4, 5…
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Highly Cited
1985
Highly Cited
1985
Angiotensin converting enzyme inhibitors: 1,5-benzothiazepine derivatives.
J. Slade
,
J. Stanton
,
D. Bendavid
,
G. C. Mazzenga
Journal of medicinal chemistry
1985
Corpus ID: 29250502
The synthesis of chiral 1,5-benzothiazepines 2a-c, 14a-c, 15c, and 16a prepared from cysteine is described. In vitro inhibition…
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Highly Cited
1975
Highly Cited
1975
Effect of diltiazem on electrical and mechanical activity of isolated cardiac ventricular muscle of guinea pig.
H. Nakajima
,
M. Hoshiyama
,
K. Yamashita
,
A. Kiyomoto
Japanese journal of pharmacology
1975
Corpus ID: 17291026
Diltiazem, a new 1,5-benzothiazepine derivative, antagonized calcium ion and thus caused a reduction in the contractile force of…
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1974
1974
Studies on a new 1,5-benzothiazepine derivative (CRD-401) VI. Effects on renal blood flow and renal function.
I. Yamaguchi
,
K. Ikezawa
,
Toshikazu Takada
,
A. Kiyomoto
1974
Corpus ID: 208658525
Abstract Effects of a new coronary vasodilator, CRD-401, on renal blood flow and renal function were investigated in anesthetized…
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Highly Cited
1973
Highly Cited
1973
Studies on a new 1,5-benzothiazepine derivative (CRD-401). IV. Coronary vasodilating effect and structure-activity relationship.
T. Nagao
,
M. Sato
,
H. Nakajima
,
A. Kiyomoto
Chemical & pharmaceutical bulletin
1973
Corpus ID: 28102416
The coronary vasodilating action of 1, 5-benzothiazepine derivatives and the structureactivity relationship were examined in the…
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Highly Cited
1972
Highly Cited
1972
Studies on a new 1,5-benzothiazepine derivative (CRD-401). 3. Effects of optical isomers of CRD-401 on smooth muscle and other pharmacological properties.
T. Nagao
,
M. Sato
,
Y. Iwasawa
,
T. Takada
,
R. Ishida
Japanese journal of pharmacology
1972
Corpus ID: 26876287
Abstract 3-Acetoxy-2, 3-dihydro-5-[2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-l, 5-benzothia-zepin-4(5H)-one hydrochloride is a…
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