.................................................................................................................................. vi Chapter 1: General Introduction .............................................................................................. 1 Chapter 2: Materials and Methods. ....................................................................................... 45 Chapter 3: Modulation of GSH oxido-reduction mechanism in the HaCaT cell line. ............. 66 Chapter 4: GSH conjugation as clearance mechanism of dinitrohalobenzenes in the HaCaT cell line. .................................................................................................................................. 99 Chapter 5: GSH conjugation of model sensitisers of various potencies: Case study for DNCB, DPCP and DEM. .................................................................................................................... 123 Chapter 6: Effect of multiple dosing of DNCB on the Reconstructed Human Epidermis model. .................................................................................................................................. 155 Chapter 7: General Discussion. ............................................................................................ 181 Bibliography. ........................................................................................................................ 190