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1,4-dihydropyrimidine

National Institutes of Health

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Pyrimidines

Papers overview

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2015
2015
Structure Based Library Design (SBLD) for new 1,4-dihydropyrimidine scaffold as simultaneous COX-1/COX-2 and 5-LOX inhibitors.
The various scaffolds containing 1,4-dihydropyrimidine ring were designed by considering the environment of the active site of… Expand
2015
2015
Design, synthesis, and computational studies on dihydropyrimidine scaffolds as potential lipoxygenase inhibitors and cancer chemopreventive agents
Dihydropyrimidine scaffold has a wide range of potential pharmacological activities such as antiviral, antitubercular… Expand
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2015
2015
ZNO-NPS AS AN EFFICIENT REUSABLE HETEROGENEOUS CATALYST FOR SYNTHESIS OF 1, 4-DIHYDROPYRIMIDINE DERIVATIVES IN SOLVENT-FREE CONDITIONS
An efficient synthesis route to 1,4-dihydropyrimidine derivatives from reaction of divergent aldehydes with ethylacetoacetate and… Expand
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2014
2014
Synthesis, in vitro Anticancer and Antimicrobial Evaluation of Novel Substituted Dihydropyrimidines
A series of 1,4-dihydropyrimidine derivatives 3(a-t) were prepared from Biginelli reactions by using ethyl acetoacetate… Expand
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2011
2011
SYNTHESIS OF 4- (2-METHYLTHIAZOL-4-YL) - HEXAHYDROQUINOLINE AND 1, 4-DIHYDROPYRIMIDIN DERIVATIVES
A series of new hexahydroquinoline and 1,4-dihydropyrimidine derivatives were synthesized. Condensation of 2-methyl- thiazole-4… Expand
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2009
2009
Synthesis and docking studies of new 1,4-dihydropyridines containing 4-(5)-Chloro-2-ethyl-5-(4)-imidazolyl substituent as novel calcium channel agonist
Abstract1,4-Dihydropyridines have been recognized as calcium channel agonist. Three new analogues of Bay K8644 in which the ortho… Expand
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2007
2007
Microwave-assisted synthesis of some novel 1,4-dihydropyrimidine derivatives of biological interest
Dihydropyrimidines are associated with broad spectrum of biological activities. In view of this 5-benzoyl-6-methyl-4-substituted… Expand
1994
1994
The effect of substituents on the conformational mobility of the heterocycle in 1,4-dihydropyrimidine and its derivatives
The equilibrium geometry of 1,4-dihydropyrimidine, 4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine, and their alkyl (Me, Et, Pri, But… Expand
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1994
1994
Imidazo[1,5-a]pyrimidine and benzo[4,5]imidazo-[1,2-a]pyrimidine derivatives as calcium antagonists.
Several bicyclic dihydropyrimidines were synthesized and evaluated for their calcium antagonistic activities by comparison with… Expand
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