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1,4-dihydropyrimidine

 
National Institutes of Health

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Pyrimidines

Papers overview

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2015
2015
Structure Based Library Design (SBLD) for new 1,4-dihydropyrimidine scaffold as simultaneous COX-1/COX-2 and 5-LOX inhibitors.
The various scaffolds containing 1,4-dihydropyrimidine ring were designed by considering the environment of the active site of… Expand
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2015
2015
Design, synthesis, and computational studies on dihydropyrimidine scaffolds as potential lipoxygenase inhibitors and cancer chemopreventive agents
Dihydropyrimidine scaffold has a wide range of potential pharmacological activities such as antiviral, antitubercular… Expand
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2015
2015
ZNO-NPS AS AN EFFICIENT REUSABLE HETEROGENEOUS CATALYST FOR SYNTHESIS OF 1, 4-DIHYDROPYRIMIDINE DERIVATIVES IN SOLVENT-FREE CONDITIONS
An efficient synthesis route to 1,4-dihydropyrimidine derivatives from reaction of divergent aldehydes with ethylacetoacetate and… Expand
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2014
2014
Synthesis, in vitro Anticancer and Antimicrobial Evaluation of Novel Substituted Dihydropyrimidines
A series of 1,4-dihydropyrimidine derivatives 3(a-t) were prepared from Biginelli reactions by using ethyl acetoacetate… Expand
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2011
2011
Synthesis of 4-(2-Methylthiazol-4-yl)-Hexahydroquinoline and 1,4-Dihydropyrimidin Derivatives
A series of new hexahydroquinoline and 1,4-dihydropyrimidine derivatives were synthesized. Condensation of 2-methyl- thiazole-4… Expand
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2009
2009
Synthesis and docking studies of new 1,4-dihydropyridines containing 4-(5)-Chloro-2-ethyl-5-(4)-imidazolyl substituent as novel calcium channel agonist
Abstract1,4-Dihydropyridines have been recognized as calcium channel agonist. Three new analogues of Bay K8644 in which the ortho… Expand
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2007
2007
Microwave-assisted synthesis of some novel 1,4-dihydropyrimidine derivatives of biological interest
Dihydropyrimidines are associated with broad spectrum of biological activities. In view of this 5-benzoyl-6-methyl-4-substituted… Expand
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1994
1994
Imidazo[1,5-a]pyrimidine and benzo[4,5]imidazo-[1,2-a]pyrimidine derivatives as calcium antagonists.
Several bicyclic dihydropyrimidines were synthesized and evaluated for their calcium antagonistic activities by comparison with… Expand
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1994
1994
The effect of substituents on the conformational mobility of the heterocycle in 1,4-dihydropyrimidine and its derivatives
The equilibrium geometry of 1,4-dihydropyrimidine, 4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine, and their alkyl (Me, Et, Pri, But… Expand
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