1,3-dimethyluric acid

Pharmacokinetic parameters of theophylline and one of its metabolites, 1,3-dimethyluric acid (1,3-DMU), were compared after… Expand

Organic anion transporter 2 (Oat2 [SLC22A7]) is a multispecific organic anion transporter. Although several substrates of human… Expand

1. Fluvoxamine and seven other selective serotonin reuptake inhibitors (SRRI) were tested for their ability to inhibit a number… Expand

Studies were undertaken to determine which human P450 enzymes catalyze the metabolism of theophylline to 1,3-dimethyluric acid (1… Expand

1. Theophylline metabolism was studied using seven human cytochrome P-450 isoforms (CYPs), namely CYP1A1, 1A2, 2A6, 2B6, 2D6, 2E1… Expand

1. A radiometric high performance liquid chromatographic method is described for the assay of theophylline metabolism in vitro by… Expand

Summary: Eleven healthy volunteers were given maintenance treatment with oral theophylline in increasing doses (210–1,260 mg/day… Expand

Theophylline (1,3-dimethylxanthine) is a constituent of numerous bronchodilator preparations and is widely used in the treatment… Expand

Elimination kinetics of theophylline and its major metabolites were investigated in 14 healthy adults in single‐dose studies and… Expand

The intermediary metabolism of theophylline has been the subject of a number of studies, but its fate in the body is still… Expand