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1'-hydroxybufuralol

 
National Institutes of Health

Papers overview

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2011
2011
A three-phase hollow-fiber liquid-phase microextraction (HF-LPME) method for the stereoselective determination of bufuralol… Expand
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2004
2004
Human liver microsomes (HLMs) are frequently utilized in drug discovery to predict the human clearance of a compound. The extent… Expand
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Highly Cited
2003
Highly Cited
2003
A method has been developed for the high-throughput inhibition screening of the major human cytochrome P450 (CYP) enzymes (CYP1A2… Expand
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Highly Cited
2002
Highly Cited
2002
In rats, six cytochrome P450 (P450) 2D isoforms have been genetically identified. Nonetheless, there is little evidence of… Expand
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Highly Cited
2001
Highly Cited
2001
Debrisoquine metabolism among Tanzanians has been found to be slower than expected from the CYP2D6 genotype. In order to evaluate… Expand
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1999
1999
The cynomolgus monkey is a species used in drug-safety evaluation and biotransformation studies by the pharmaceutical industry… Expand
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Highly Cited
1994
Highly Cited
1994
Bufuralol 1'-hydroxylation is a prototypical reaction catalyzed by cytochrome P450 (P450) 2D6, an enzyme known to show… Expand
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Highly Cited
1993
Highly Cited
1993
To gain insight into the specificity of cytochrome P-450 2D6 toward inhibitors, a preliminary pharmacophore model was built up… Expand
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1991
1991
A 34-year-old man with bipolar manic depressive illness suffered from severe adverse effects during treatment with amitriptyline… Expand
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Highly Cited
1987
Highly Cited
1987
Bufuralol, debrisoquine, and dextromethorphan are three prototype substrates of the common genetic deficiency of oxidative drug… Expand
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