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The present study aims at predicting the level of formation of the ultimate carcinogenic metabolite of methyleugenol, 1… Expand Methyleugenol--a natural constituent of herbs and spices--is hepatocarcinogenic in rodent models. It can form DNA adducts after… Expand Methyleugenol (ME) occurs naturally in a variety of spices, herbs, including basil, and their essential oils. ME induces… Expand This study defines a physiologically based kinetic (PBK) model for methyleugenol (ME) in human based on in vitro and in silico… Expand Methyleugenol is a substituted alkenylbenzene classified by the European Union's Scientific Committee on Food as a genotoxic… Expand The present study defines a physiologically based biokinetic (PBBK) model for the alkenylbenzene methyleugenol in rat based on in… Expand In vitro studies were performed to elucidate the human cytochrome P450 enzymes involved in the bioactivation of methyleugenol to… Expand Cytochrome P450 mediated metabolism of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol has been investigated in… Expand cytochrome P450 enzyme system (3). The 1 9-hydroxy metabolCytochrome P450 mediated metabolism of methyleugenol ites are then… Expand Methyleugenol is an allylbenzene food flavoring which has been shown to form DNA and protein adducts, and to cause hepatotoxicity… Expand